Physicians now have a formidable new weapon against resistant hyperpigmentation with Cosmelan M.D. Depigmentation Treatment by Mesoestetic USA, Encino, CA. The recently-released formula advances the science of pigment correction to its most effective capabilities ever with a fast-acting combination of retinoic acid and prescription-strength hydroquinone. The treatment acts within the cells responsible for skin pigmentation, inhibiting the cycle of melanogenesis, or the production of melanin, which causes the deposit of pigment in the skin. The Cosmelan method eliminates the challenge of chemical peels with a non-invasive depigmentation action that is compatible with all skin types, from fair skin to dark skin and the many variations in between. Improvements may be seen as early as two weeks with the new hydroquinone-based formula.