11.09.17
US Patent No. 9,801,811 B1; The Procter & Gamble Company has patented a stable skin care composition for improving the appearance of aging skin. The composition is comprised of a) artichoke leaf extract; a carob fruit extract; a skin tone agent selected from the group consisting of vitamin B3 compounds, sugar amines, hexamidine compounds, salicylic acid, 1,3-dihydroxy-4-alkylbenzene, retinoids, and combinations thereof; and dermatologically acceptable carrier. The composition excludes materials that complex with the artichoke leaf extract and the carob fruit extract, and wherein the artichoke leaf extract and the carob fruit extract are present at an amount to provide a synergistic increase in the up-regulation of at least one epidermal-associated gene selected from the group consisting of KRT2, KRT6A, CLDN1, LOR, FLG, IVL, KRT10, AQP3, and KRT14 according to an ex vivo tissue analysis.
