In the rush to market and the pressure to accomplish this on shorter development schedules, scale-up is often an afterthought.The ability to easily and predictably manufacture your finished product is a crucial step in any product development. It is also essential to formula ownership.
Also, order of ingredient additions can have a large impact in a production environment when it appeared to have no issues on the bench. Chemists must be mindful to the transitions in their batches as each ingredient is added. An extended mixing time on the bench to fully incorporate an addition will necessitate adjustments for larger batches as this type of mixing and time are not available. Often production issues are caused by improper procedure originating at the bench. Temperature and mixing requirements are as important to formula success as the ingredient itself.
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