Formulary

Deep Wrinkle Treatment

October 1, 2005


Phase A
Deionized water
75.90
Glycerin
2.00

Phase B
Crodafos CES (Croda) (Cetearyl alcohol and dicetyl phosphate and cetheth-10 phosphate)
5.00
Crodacol C-70 (Croda) (Cetyl alcohol)
0.25
Crodamol STS (Croda) (PPG-3 benzyl ether myristate)
5.00
Crodarom avocadin (Croda) (Persea gratissima [avocado] oil unsaponifiables)
0.50
Shea butter (Sederma) (Butyrospermum parkii)
3.00
Dermaxyl (Sederma) (C12-15 alkyl benzoate and tribehenin and ceramide 2 and PEG-10 rapeseed sterol and palmitoyl oligopeptide)
2.00
Cyclomethicone (Dow Corning)
1.00

Phase C
Deionized water
2.00
Sodium hydroxide pellets
0.30

Phase D
Matrixyl 3000 (Sederma) (Glycerin and water and butylene glycol and carbomer and polysorbate 20 and palmitoyl oligopeptide and palmitoyl tetrapeptide-3)
3.00
Methylisothiazolinone
0.05

Procedure
Combine ingredients of phase A and mix. Begin heating to 75-80°C. Combine ingredients of phase B (excluding cyclomethicone) in separate beaker and heat with mixing to 75-80°C. Add phase A to phase B with strong agitation, maintaining temperature at 75-80°C for 10 minutes. Add cyclomethicone with mixing. Begin cooling. Combine phase C ingredients and add to phase A/B with mixing at 60°C. When batches reaches 40°C, add phase D with mixing. When batch reaches room temperature, check pH and adjust if necessary.

More Information
Croda Inc., 300-A Columbus Circle, Edison, NJ, 08837
Tel: (973) 644-4900; Fax: (973) 644-9222; Website: www.crodausa.com
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