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Lipotec Debuts Novel Peptides

September 13, 2012

Delisens and Telangyn treat sensitive skin.

The latest developments from Lipotec are peptides Delisens and Telangyn directed at treating skin disorders that characterizes sensitive skin. Marine-based HA-booster Hyanify is also among its new active ingredients.

Delisens relieves itching while helps sensitive skin to recover its physiological tolerance threshold: it proved in vitro to highly counteract the release of inflammatory cytokines induced by cosmetic allergens. This novel hexapeptide innovates in the attenuation of neurogenic inflammation by modulating the activity of Proteinase-Activated Receptor 2 (PAR-2), crucially involved in the processing of pruritic and/or inflammatory signals.

Delisens mitigates the stinging and burning effect induced by capsaicin and acid lactic on the skin, as shown in vivo. Moreover, it protects the human dermal fibroblasts against UV radiation and stimulates the proliferation of human keratinocyte contributing to the restoring of the barrier function and the integrity of skin tissue.

Telangyn decreases the appearance of facial redness by reducing the levels of interleukins IL-6 and IL-8, which are induced by the antimicrobial peptide LL-37. The expression of this antimicrobial peptide is abnormally high in skin disorders with erythema and dilated bloods vessels, such as rosacea. Moreover and thanks to its significant anti-collagenase and anti-tyrosinase activities, Telangyn helps to improve skin firmness, elasticity and the evenness of the skin tone. This is a tetrapeptide, which also provides a high photoprotective effect to the skin, lowering cell damage.

From marine biotechnology through biofermentation, Hyanify is an exopolysaccharide with efficacy in boosting the synthesis of hyaluronic acid in the skin, offering an efficient replenishing effect against wrinkles. As show in vivo, nasolabial folds reduced in only 14 days of treatment with 1% Hyanify Solution, said the company. HA availability decreases with aging, altering the balance between synthesis and degradation, which leads to dehydration of the skin and volume loss.

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