Cosmetic injectable fillers first hit the market in 1981, when the FDA approved Zyderm (an animal-based collagen). Over the next 22 years, injectable fillers were only available in either animal-based or human-based collagen, posing difficulties for some patients who had adverse allergic reactions to these substances. Hyaluronic acid changed the face of the U.S. injectable scene in 2003 when Restylane first received approval from the FDA. Hyaluronic acid (HA) is a naturally occurring sugar within the body that was first discovered in the 1930s; since the body naturally produces HA there were far fewer allergic reactions and complications. There are now several injectable filler substances on the market, but they all aim to correct the same thing: add volume to facial tissue where moderate to severe wrinkles and folds occur.
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