Florence Trombini , BASF09.01.15
Estimates of the value of the global anti-aging market and projections for its future volume vary considerably depending on which market segments researchers include in their models. However, one thing is certain: anti-aging products and services are becoming ever more prominent. As Transparency Market Research pointed out in its 2013 survey, aging baby boomers have spurred demand for products and services that can either reverse or slow the signs of aging, while members of Generation Y are already fighting fine lines and early wrinkles.
Across generations, there is growing demand for high-performing anti-aging products. Inspired by life, the latest anti-aging active ingredients from BASF restore skin firmness, make the skin’s surface smoother and enhance the skin’s complexion, allowing manufacturers in the personal care market to create cosmetic products that meet consumers’ innermost needs and desires. Here are details on several new anti-aging ingredients.
Lox-Age for a Perfect Skin Surface
Lox-Age uses the power of chicory (Cichorium intybus) to restore expression of lysyl oxidase (LOX), a key protein that becomes scarce with age. The expression of LOX is directly linked with the differentiation of keratinocytes, the predominant cell type in the epidermis. Lox-Age stimulates the expression of LOX in aged keratinocytes, thus strengthening the skin’s epidermal structure and cohesion. When Lox-Age is applied, the expression of LOX in the epidermis is restored to a similar level to that found in young skin.
In a clinical study, Lox-Age 2% improved roughness of the skin by 62% and decreased visible pores by 25% after eight weeks of application. As fine lines and visible pores fade, new, smoother skin appears. The chicory extract fades skin blemishes to perfection, restoring the skin’s vitality and giving it a youthful look. The skin appears revitalized and free of the most visible signs of aging.
Lox-Age is suitable for smoothing, anti-wrinkle treatments, pore-refining treatments, moisturizing treatments, epidermis-restructuring treatments and pore de-aging serums.
Epigenist, the Epidermal Rejuvenator
BASF’s new active ingredient, Epigenist, boosts neuritogenesis in the epidermis, reversing the natural degradation of nerve fibers. Extracted from the African bambara pea (Voandzeia subterranea), this new active rejuvenates the skin: Epigenist improves the skin’s structure and visibly increases its thickness.
In vivo studies were conducted with the help of 20 female volunteers. After eight weeks of treatment with Epigenist 0.5% versus a placebo, epidermal thickness increased by 10% (confocal microscopy measurement). At the same time, skin roughness scores (Stm and SA) were reduced (based on topography analysis of data obtained by fringes projection)—the active also produced a skin-smoothing effect, and wrinkles were reduced compared to the placebo treatment.
Epigenist is suitable for daily anti-aging treatments, anti-dull skin products and for the treatment of fine wrinkles.
Perlaura, the Skin Aura Designer
An aqueous extract from the roots of meadow bistort (Polygonum bistorta), Perlaura stimulates the expression of the fibrous protein perlecan and its receptor dystroglycan, which contribute to skin homeostasis in the epithelial and endothelial basement membranes. Unfortunately, perlecan and dystroglycan expression declines rapidly with age, but by acting on these two targets, the anti-aging active contributes to restoring the skin’s integrity: the skin appears brighter and smoother in just four weeks.
A full-face study was conducted before and after treatment on a panel of 45 volunteers aged between 25 and 65 years old. They were selected for their type I to III phototypes, dull complexions, and wrinkles around their eyes. For four weeks, Perlaura 1% was applied to the whole face twice daily. The results were evaluated by a clinical expert on the basis of digital images captured by VISIA-CR (Canfield). Images were obtained before the treatment, after two weeks, and after four weeks. The active ingredient was shown to increase the skin’s radiance by 42% and to increase skin softness by 23% in just four weeks.
Perlaura is recommended for reducing the effects of aging, adding radiance and restoring brightness, as a daily anti-dullness treatment, and an anti-fatigue treatment for the eye area, inter alia.
Collrepair DG Reverses Glycation
Glycation is one of the major causes of skin aging. It is the result of the typical covalent bonding of a protein or lipid molecule with a sugar molecule such as glucose, and the first step in the evolution of dreaded advanced glycation end products (AGEs), which are produced through a complex series of biochemical reactions. AGEs accumulate over time: Slowly and irreversibly, glycation damages the structure of the cells and the extracellular matrix, and thus the structure of the skin. As a result of this damage, the skin loses its elasticity and resilience, skin tone is altered through yellowing, and surface wrinkles start to appear.
There has been a lot of research aimed at preventing glycation and there are a number of active ingredients that effectively protect against it, including aminoguanidine, carnosine, Collguard and arganyl. But in the past few decades, little progress has been made in finding ways to reverse the process and bring about a decrease in the skin’s total glycation level.
Now, a breakthrough has been made in matrix fiber management: With their new active ingredient, Collrepair DG, experts from BASF Beauty Care Solutions have found a way to reverse 20 years of glycation within four months.
In vivo, Collrepair DG 3% reduced the quantity of AGEs in the skin by 4% after 16 weeks of treatment, equivalent to approximately 20 years of AGE accumulation, and reduced skin yellowing, as measured by image analysis, by 8% during the same period. It also significantly improved the skin’s elastic recovery.
Skin care products utilizing Collrepair DG help make the skin firmer, more radiant and more elastic. The new active ingredient is recommended for use in creams, lotions, and tonics.
Science Excellence Inspired by Life
Consumers around the world, Baby Boomers, Generation X, and soon Generation Y, are looking for the most effective anti-aging products that will make them look as young as they feel. Through their scientific excellence, the experts at BASF have resourcefully found ways to extract powerful anti-aging properties from natural sources: Epigenist, Lox-Age, Perlaura and Collrepair DG all offer formulators of personal care products high-performance active ingredients for use in state-of-the-art anti-aging solutions.
Florence Trombini is marketing manager, Europe Beauty Creations BASF. More info: http://personal-care.basf.com/?utm_source=HAP&utm_medium=ContentMarketing&utm_campaign=HAP; http://www.carecreations.basf.com/?utm_source=HAP&utm_medium=ContentMarketing&utm_campaign=HAP.
Across generations, there is growing demand for high-performing anti-aging products. Inspired by life, the latest anti-aging active ingredients from BASF restore skin firmness, make the skin’s surface smoother and enhance the skin’s complexion, allowing manufacturers in the personal care market to create cosmetic products that meet consumers’ innermost needs and desires. Here are details on several new anti-aging ingredients.
Lox-Age for a Perfect Skin Surface
Lox-Age uses the power of chicory (Cichorium intybus) to restore expression of lysyl oxidase (LOX), a key protein that becomes scarce with age. The expression of LOX is directly linked with the differentiation of keratinocytes, the predominant cell type in the epidermis. Lox-Age stimulates the expression of LOX in aged keratinocytes, thus strengthening the skin’s epidermal structure and cohesion. When Lox-Age is applied, the expression of LOX in the epidermis is restored to a similar level to that found in young skin.
In a clinical study, Lox-Age 2% improved roughness of the skin by 62% and decreased visible pores by 25% after eight weeks of application. As fine lines and visible pores fade, new, smoother skin appears. The chicory extract fades skin blemishes to perfection, restoring the skin’s vitality and giving it a youthful look. The skin appears revitalized and free of the most visible signs of aging.
Lox-Age is suitable for smoothing, anti-wrinkle treatments, pore-refining treatments, moisturizing treatments, epidermis-restructuring treatments and pore de-aging serums.
Epigenist, the Epidermal Rejuvenator
BASF’s new active ingredient, Epigenist, boosts neuritogenesis in the epidermis, reversing the natural degradation of nerve fibers. Extracted from the African bambara pea (Voandzeia subterranea), this new active rejuvenates the skin: Epigenist improves the skin’s structure and visibly increases its thickness.
In vivo studies were conducted with the help of 20 female volunteers. After eight weeks of treatment with Epigenist 0.5% versus a placebo, epidermal thickness increased by 10% (confocal microscopy measurement). At the same time, skin roughness scores (Stm and SA) were reduced (based on topography analysis of data obtained by fringes projection)—the active also produced a skin-smoothing effect, and wrinkles were reduced compared to the placebo treatment.
Epigenist is suitable for daily anti-aging treatments, anti-dull skin products and for the treatment of fine wrinkles.
Perlaura, the Skin Aura Designer
An aqueous extract from the roots of meadow bistort (Polygonum bistorta), Perlaura stimulates the expression of the fibrous protein perlecan and its receptor dystroglycan, which contribute to skin homeostasis in the epithelial and endothelial basement membranes. Unfortunately, perlecan and dystroglycan expression declines rapidly with age, but by acting on these two targets, the anti-aging active contributes to restoring the skin’s integrity: the skin appears brighter and smoother in just four weeks.
A full-face study was conducted before and after treatment on a panel of 45 volunteers aged between 25 and 65 years old. They were selected for their type I to III phototypes, dull complexions, and wrinkles around their eyes. For four weeks, Perlaura 1% was applied to the whole face twice daily. The results were evaluated by a clinical expert on the basis of digital images captured by VISIA-CR (Canfield). Images were obtained before the treatment, after two weeks, and after four weeks. The active ingredient was shown to increase the skin’s radiance by 42% and to increase skin softness by 23% in just four weeks.
Perlaura is recommended for reducing the effects of aging, adding radiance and restoring brightness, as a daily anti-dullness treatment, and an anti-fatigue treatment for the eye area, inter alia.
Collrepair DG Reverses Glycation
Glycation is one of the major causes of skin aging. It is the result of the typical covalent bonding of a protein or lipid molecule with a sugar molecule such as glucose, and the first step in the evolution of dreaded advanced glycation end products (AGEs), which are produced through a complex series of biochemical reactions. AGEs accumulate over time: Slowly and irreversibly, glycation damages the structure of the cells and the extracellular matrix, and thus the structure of the skin. As a result of this damage, the skin loses its elasticity and resilience, skin tone is altered through yellowing, and surface wrinkles start to appear.
There has been a lot of research aimed at preventing glycation and there are a number of active ingredients that effectively protect against it, including aminoguanidine, carnosine, Collguard and arganyl. But in the past few decades, little progress has been made in finding ways to reverse the process and bring about a decrease in the skin’s total glycation level.
Now, a breakthrough has been made in matrix fiber management: With their new active ingredient, Collrepair DG, experts from BASF Beauty Care Solutions have found a way to reverse 20 years of glycation within four months.
In vivo, Collrepair DG 3% reduced the quantity of AGEs in the skin by 4% after 16 weeks of treatment, equivalent to approximately 20 years of AGE accumulation, and reduced skin yellowing, as measured by image analysis, by 8% during the same period. It also significantly improved the skin’s elastic recovery.
Skin care products utilizing Collrepair DG help make the skin firmer, more radiant and more elastic. The new active ingredient is recommended for use in creams, lotions, and tonics.
Science Excellence Inspired by Life
Consumers around the world, Baby Boomers, Generation X, and soon Generation Y, are looking for the most effective anti-aging products that will make them look as young as they feel. Through their scientific excellence, the experts at BASF have resourcefully found ways to extract powerful anti-aging properties from natural sources: Epigenist, Lox-Age, Perlaura and Collrepair DG all offer formulators of personal care products high-performance active ingredients for use in state-of-the-art anti-aging solutions.
Florence Trombini is marketing manager, Europe Beauty Creations BASF. More info: http://personal-care.basf.com/?utm_source=HAP&utm_medium=ContentMarketing&utm_campaign=HAP; http://www.carecreations.basf.com/?utm_source=HAP&utm_medium=ContentMarketing&utm_campaign=HAP.