11.02.16
US Patent No. 9,434,993 B2; The Procter & Gamble Company has patented a system for identifying connections between a cosmetic agent and at least one gene associated with a skin aging condition.
The patent entails at least one computer readable medium having stored thereon a plurality of instances and a skin aging gene expression signature, wherein each instance comprises an ordered list of identifiers representing a plurality of up-regulated and a plurality of down-regulated genes differentially expressed in response to contact between the cosmetic agent and a human fibroblast cell or a human keratinocyte cell. The skin aging gene expression signature comprises one or more lists comprising a plurality of identifiers representing a plurality of up-regulated genes and a plurality of down-regulated genes associated with a skin aging condition. It also includes about 80% to about 100% of the plurality of identifiers associated with the skin aging gene expression signature representing a gene set forth in any of Tables A to D.
The patent entails at least one computer readable medium having stored thereon a plurality of instances and a skin aging gene expression signature, wherein each instance comprises an ordered list of identifiers representing a plurality of up-regulated and a plurality of down-regulated genes differentially expressed in response to contact between the cosmetic agent and a human fibroblast cell or a human keratinocyte cell. The skin aging gene expression signature comprises one or more lists comprising a plurality of identifiers representing a plurality of up-regulated genes and a plurality of down-regulated genes associated with a skin aging condition. It also includes about 80% to about 100% of the plurality of identifiers associated with the skin aging gene expression signature representing a gene set forth in any of Tables A to D.