Rodan & Fields Patents Method to Make TPM Liposomal Compositions

US Patent No. 12,059,486 B2 (George P. Majewski, Christine Crane, John Simon Craw, Gabriele Di Fiore, Dzung Q. Le, Olga Dueva-Koganov, Robert Bianchini, Angela M. Rivera); Rodan & Fields, LLC, San Francisco, CA, has patented a method for preparing a method for preparing a tocopherol phosphate mixture (TPM) liposomal composition. It comprises the following steps:

A: mixing a lipophilic ingredient with a polar solvent system and heating the resulting mixture to a temperature of at least about 60°C;

B: adding a mixture of tocopherol phosphate derivative ingredients to the mixture from step a) once temperature reaches about 57.9°C and maintaining the temperature sufficient to melt all contents, wherein the mixture of tocopherol phosphate derivative ingredients are selected from alpha-tocopheryl phosphate (TP), di-alpha-tocopheryl phosphate (T2P), beta tocopherol phosphate, gamma tocopherol phosphate, delta tocopherol phosphate, or a combination thereof;

C: cooling the mixture from step B to a temperature of about 32°C to about 35°C, adding one or more lipophilic ingredients and ethanol into the cooled mixture, and mixing the mixture until complete dissolution to form Phase A;

D: mixing, in a separate container, one or more water soluble ingredients, and water thoroughly at a temperature of about 38°C to about 40°C to form Phase B;

E: adding Phase A into Phase B and mixing at a temperature of about 38° C. to about 40° C. for at least 20 minutes;

F: adding a neutralizing base to the mixture of step E

G: dispersing xanthan gum into glycerin to form Phase C and mixing Phase C into the mixture of step F and;

H: turning off the heat to the mixture of step G and stirring the mixture until the temperature of the mixture reaches room temperature, thereby forming the TPM liposomal composition.