New Data on Squalane in CBD Delivery

Natural sugarcane squalane is a superior carrier versus other oils, according to Amyris.

Amyris, Inc. has presented clinical data showcasing the superiority of its natural sugarcane squalane (marketed and sold as Neossance Squalane) as a carrier of CBD versus other oils. 

In order for CBD to be effective in topical applications, skin penetration is a key factor. According to Amyris, sugarcane squalane improves the efficacy of CBD by 10-40X as the carrier oil chassis for the skin care market based on new data.
The Cosmos Technical Center recently conducted a study to explore the skin penetration rate of CBD in Neossance Squalane versus jojoba oil, sunflower oil, MCT (medium-chain triglycerides), and hemp seed oil into human skin. The study measured the amount of CBD penetrated in a human epidermal skin model and found that Neossance Squalane delivered between 10-40 times more CBD to the epidermis than other carrier oils. The results also illustrated that CBD when used with Neossance Squalane penetrated skin faster, an important aspect for quicker and impactful skin relief, said the firm.


Graph represents concentration of CBD measured in the EpiSkin model at various time points comparing delivery in Neossance Squalane, Jojoba Oil, Sunflower Oil, MCT, and Hemp Seed Oil. Neossance Squalane has improved CBD penetration across all time points.

The other oils tend to rest on the surface of the skin along with some of the CBD being carried, or clog skin pores without delivering a sufficient quantity of CBD as desired to the epidermis of the skin where it matters. Brands should prioritize effective delivery of CBD to where receptors are in the skin; Neossance Squalane can be used as a chassis to deliver the best penetration performance to significantly improve the efficacy of CBD for topical applications, according to the company. Neossance Squalane can also improve consumer experience as it provides to the skin benefits like moisturizing, brightening, and reducing the appearance of fine lines and wrinkles. 
Amyris is developing CBD through fermentation technology and believes it will be the first company to provide highly pure and efficacious CBD from this technology at commercial scale. The company has filed a patent application covering the use of squalane to deliver cannabinoids, including CBD, to the skin to protect its distinctive advantage.
“We are very pleased with the breakthrough results from our clinical studies,” said Caroline Hadfield, president of Aprinnova. “This is a great example of how clean ingredients made from our science platform and naturally sourced from sugarcane combined with our scientific approach to formulations can lead to disruption in key markets. We are very excited to deliver what consumers are seeking and support the brands that are committed to delivering high efficacy and sustainability at an accessible value for consumers.”

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