• Login
    • Join
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Formulary
    • Exclusives
    • Top Companies
    • Raw Materials
    • End-User
    • Packaging
    • Directories
    • Events
    • Jobs
    • More
  • Magazine
  • News
  • Formulary
  • Exclusives
  • Top Companies
  • Raw Materials
  • End-User
  • Packaging
  • Directories
  • Events
  • Jobs
  • Current / Back Issues
    Features
    Columns
    Editorial
    Digital Edition
    eNewsletter Archive
    Our Team
    Editorial Guidelines
    Subscribe Now
    Advertise Now
    Top Features
    Shape Up!

    Connecting To The Consumer

    Enhancing Cosmeceuticals Via Phytonutrients

    Building on Its Strength

    Pardon the Disruption
    Online Exclusives
    Association News
    Breaking News
    Financial News
    Industry News
    International
    Marketing News
    New Products
    News Front
    Packaging News
    Patents
    Personnel
    Regulations
    Snapshots
    Top News
    Live From Shows
    Top News
    Put Nagase to the Test!

    WWP Buys CDG & Design Quest

    Magnakron To Build Coconut Plant

    BASF Invests in Digital

    Not Too Cool for School!
    Blog
    Online Exclusives
    Infographics
    Podcasts
    Whitepapers
    Videos
    Expert's Opinion
    Surveys
    International Top 30 Report
    Top 50 Report
    Top Companies
    2. Colgate-Palmolive

    20. Clarins

    12. Sealed Air Diversey

    37. Phoenix Brands

    39. American International Industries
    Actives
    Functional Ingredients
    Pigments
    Polymers
    Preservatives
    Surfactants

    Put Nagase to the Test!

    BASF Invests in Digital

    Not Too Cool for School!

    schülke's Products are Halal-Certified

    PRIA On-Track for Reauthorization
    Air Care/Environmental Fragrance
    AP/Deo
    Color Cosmetics
    Disinfectants
    Fine Fragrance
    Hair Care
    Household Cleaning
    I&I Marketplace
    Laundry Care
    Oral Care
    OTC/Medicated
    Packaging
    Personal Cleansers
    Skin Care
    Sun Care
    Testing

    Put Nagase to the Test!

    WWP Buys CDG & Design Quest

    Not Too Cool for School!

    Anisa Opens LA Office

    schülke's Products are Halal-Certified
    Lab Equipment
    Mixing
    Packaging
    Testing

    WWP Buys CDG & Design Quest

    Anisa Opens LA Office

    Plastic Problem? Look to Squid Inc.

    Method Unveils Spring Limited Edition Line

    More Eco Options Roll Out in Laundry Space
    Contract Manufacturing / Private Label Directory
    Buyer's Guide
    Add New Company
    Corporate Profiles
    International Buyers Guide Companies
    Sabinsa Cosmetics, a division of Sabinsa Corporation

    Ashland

    Croda

    CIE

    Siltech Corporation
    Live From Shows
    Meetings
    Webinars
    Snapshots
    • Magazine
      • Current / Back Issues
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Formulary
    • Directories
      • Buyer's Guide
      • Contract Manufacturing / Private Label Directory
      • Corporate Profiles
      • Add Your Company
    • Raw Materials
      • Actives
      • Functional Ingredients
      • Pigments
      • Polymers
      • Preservatives
      • Surfactants
    • End-User
      • Air Care/Environmental Fragrance
      • AP/Deo
      • Color Cosmetics
      • Disinfectants
      • Fine Fragrance
      • Hair Care
      • Household Cleaning
      • I&I Marketplace
      • Laundry Care
      • Oral Care
      • OTC/Medicated
      • Packaging
      • Personal Cleansers
      • Skin Care
      • Sun Care
      • Testing
    • Packaging
      • Lab Equipment
      • Mixing
      • Packaging
      • Testing
    • Top Companies
      • International Top 30 Report
      • Top 50 Report
    • Online Exclusives
    • Experts Opinion
    • Slideshows
    • Videos
    • Podcasts
    • Infographics
    • Blog
    • Whitepapers
    • Surveys
      • R & D Salary Survey
      • Sales & Marketing Salary Survey
    • Job Banks
    • Events
      • Industry Events
      • Live from show Events
      • Webinars
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    Inflammation Resolution During Skin Aging

    Gattefossé and Ambiotis investigate this potentially disruptive action.

    Related CONTENT
    • Take the Holistic Approach to Inner & Outer Well-Being
    • Their Own Devices
    • New Marine Active from Alban Muller
    • Science-Driven Women Named To Sephora Accelerate Cohort
    • Defensins Are a New Anti-Aging Weapon
    05.09.18
    Inflammation is a major concern in dermatology and for skin health. Daily stress, lack of sleep, improper diet, pollution, sun exposure and aging itself can all trigger a lowgrade inflammation in the skin. Inflammation is a natural system of defense against external and internal aggressions. When correctly controlled, inflammation leads to a complete return to tissue equilibrium. However, a default in inflammation resolution pathways may directly impact both appearance and beauty of the skin. 


    To better understand the muted, asymptomatic and chronic inflammation related to skin aging, Gattefossé and Ambiotis carried out investigation to unravel the underlying mechanisms leading to non-resolving inflammation, also called Inflamm’ Aging. 


    A skin explant model was developed in vitro by Gattefossé to simulate the natural triggering of skin inflammation and its subsequent regulation. Using its thorough expertise in metabololipidomic profiling, Ambiotis developed and validated a LC-MS/MS method to monitor the response to inflammation of skin explants and their ability to initiate resolution programs. 


    Gattefossé and Ambiotis now share technology, expertise and know-how to explore the mechanisms of skin inflammation resolution during ageing. Skin produces bioactive mediators that regulate induction, propagation and resolution of inflammation. Specialized Pro-resolving lipid Mediators (SPMs) are of special importance for an effective resolution of inflammation. Ambiotis and Gattefossé found out that endogenous resolution programs of inflammation were defective in aged skin. Both the dysregulation of lipid pathways and the absence of pro-resolving mediators (e.g. lipoxins) likely lead to an unresolved inflammation in aged skin. 


    “Resolution of inflammation is a complete paradigm shift in the field of inflammation. The discovery of SPMs and their role in the last decade has indeed changed the view to solve inflammatory processes: boosting resolution circuits appears a powerful strategy to rectify chronic inflammatory status," said Ambiotis CEO Marc Dubourdeau. "Different approaches can be developed: agonists of resolution targets, mimetics of SPMs… Our company has dedicated its research to the validation of assays to help our partners develop ingredients with pro-resolution capacities. We are very enthusiastic about this collaboration with Gattefossé."


    According to Dubourdeau, the project on skin will open new perspectives for dermo-cosmetic applications. Researchers at Gattefossé agree. 


    “By performing metabololipidomic profiling of young vs. old skins, followed by a statistical approach using principal component analysis, we have been able to identify the defective elements responsible for unresolved inflammation in aged skins," said Nicolas Bechetoille, skin biology research manager, Gattefossé, "Our research highlights the need of a new strategy to develop anti-inflammatory molecules, rather focused on boosting resolution than on decreasing inflammation.”


    This work will be presented at the 2018 International Investigative Dermatology, May 16-19 in Orlando, Florida, US.
    Related Searches
    • asian
    • dermatology
    • ingredients
    • skin
    Related Knowledge Center
    • OTC/Medicated
    • Surfactants
    • Testing
    Suggested For You
    Healthy Perfection from Naolys Healthy Perfection from Naolys
    Gattefossé Recharges Skin Gattefossé Recharges Skin
    Health Is Wealth Health Is Wealth
    Fermented Actives from Oat Cosmetics Fermented Actives from Oat Cosmetics
    Fermented Actives from Oat Cosmetics Fermented Actives from Oat Cosmetics
    Lessonia Launches Healthyskin Lessonia Launches Healthyskin
    Berg + Schmidt Enables Effective Use of Rutin Berg + Schmidt Enables Effective Use of Rutin
    Seiwa Kasei Launches Amitose R-PD Seiwa Kasei Launches Amitose R-PD
    Gattefossé Launches EnergiNius Gattefossé Launches EnergiNius
    Corum Launches Apobac Corum Launches Apobac
    A Gentle Approach to Acne A Gentle Approach to Acne
    Ashland Is Always Solving Ashland Is Always Solving
    Gattefossé Recharges Skin Gattefossé Recharges Skin
    Defensins Are a New Anti-Aging Weapon Defensins Are a New Anti-Aging Weapon
    Science-Driven Women Named To Sephora Accelerate Cohort Science-Driven Women Named To Sephora Accelerate Cohort

    Related Breaking News

    • Functional Ingredients | Skin Care | Testing
      Put Nagase to the Test!

      Put Nagase to the Test!

      A range of advanced efficacy tests for personal care formulas.
      02.22.19

    • Skin Care

      Skin Care Actives from DSM

      Learn more at PCHi, stand 4D28.
      02.22.19

    • Actives | Color Cosmetics | Functional Ingredients | Hair Care | Personal Cleansers | Pigments | Polymers | Preservatives | Skin Care | Sun Care | Surfactants | Testing
      Not Too Cool for School!

      Not Too Cool for School!

      NYSCC looks at what they're teaching kids these days!
      02.22.19


    • Functional Ingredients | Hair Care | Personal Cleansers | Preservatives | Skin Care | Sun Care
      schülke

      schülke's Products are Halal-Certified

      Demand for these ingredients is surging.
      02.22.19

    • Actives | Functional Ingredients | Insect Control | Polymers | Testing
      PRIA On-Track for Reauthorization

      PRIA On-Track for Reauthorization

      HCPA urges the House to move quickly on the measure.
      02.22.19

    • Actives | Color Cosmetics | Functional Ingredients | Hair Care | Personal Cleansers | Pigments | Polymers | Preservatives | Skin Care | Sun Care | Surfactants | Testing
      In-Cosmetics Program Is Set

      In-Cosmetics Program Is Set

      Register now for Paris event, April 2-4.
      02.22.19


    • OTC/Medicated | Skin Care
      Microdart Patch Treats Acne

      Microdart Patch Treats Acne

      Zitsticka's "Killa" is a new transdermal spot treatment.
      02.22.19

    • Functional Ingredients | Household Cleaning | I&I Marketplace | Surfactants
      Your Car Is Dirtier than a Rest Stop

      Your Car Is Dirtier than a Rest Stop

      But Clorox Professional hopes to change all that.
      02.22.19

    • Actives | Color Cosmetics | Skin Care

      Amorepacific Patents Cosmetic To Block Blue Light

      Chuncheon jade powder is the active ingredient.
      02.22.19


    • Insect Control | OTC/Medicated | Skin Care

      Sunsect Patents Sunscreen and Insect Repellant

      Tallahassee, FL-based company's formulation granted protection by USPTO.
      02.22.19

    • Hair Care | Lab Equipment | Mixing | Personal Cleansers | Skin Care | Sun Care

      Versatile Mixer from Ross

      VMC VersaMix is ideal for temperature-critical formulas.
      02.22.19

    • Hair Care | Testing
      Herbal Essences Is Cruelty-Free

      Herbal Essences Is Cruelty-Free

      P&G brand earns a spot on PETA's 'beauty without bunnies' list.
      02.21.19

    • Actives | OTC/Medicated | Sun Care
      FDA Advances Proposed Rule on Sunscreens

      FDA Advances Proposed Rule on Sunscreens

      Proposed rule will update regulatory requirements for most sunscreen products in the US.
      02.21.19

    • Actives | Color Cosmetics | Skin Care | Sun Care

      IFF Acquires The Additive Advantage

      Offer pllatform that will enable the printing of flavors, fragrances, cosmetic and health and nutrition actives on consumer products.
      02.20.19

    • Color Cosmetics | Pigments | Skin Care

      Karl Lagerfeld Dies

      Chanel fashion designer was 85.
      02.19.19

    Breaking News
    • Put Nagase to the Test!
    • WWP Buys CDG & Design Quest
    • Magnakron To Build Coconut Plant
    • Skin Care Actives from DSM
    • BASF Invests in Digital
    View Breaking News >
    CURRENT ISSUE

    February 2019

    • Shape Up!
    • Connecting To The Consumer
    • Enhancing Cosmeceuticals Via Phytonutrients
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • privacy policy
    • term and condition
    • about us
    • contact us

    follow us

    Subscribe

    magazines

    Image
    Image
    Image
    Image
    Image
    Image
    Image
    Image
    Image
    Image
    Image

    Copyright © 2019 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login