Synastol TC (INCI: Terminalia chebula Fruit Extract), is a hydrophilic broad-action antioxidant. Comparative performance of Synastol TC far exceeds the antioxidant ability of many alternative fruit extracts and the commonly used antioxidant α-Tocopherol. Trolox is a water-soluble version of Vitamin E (Tocopherol).
Therefore, from these results, it is not surprising that Synastol TC was found to be very effective in reducing pollution and blue lightinduced oxidative stress at very low concentrations in a model using human epidermal keratinocytes.
Meanwhile, HydraSynol IDL (INCI: Isosorbide Disunflowerseedate) is clinically proven to boost skin hydration and reduce transepidermal water loss. Filaggrin (FLG) plays a central role in normal skin barrier function, barrier integrity maintenance and is required for the normal biogenesis and physiology of the SC.FLG is also directly responsible for Natural Moisturizing Factor (NMF) production. HydraSynol IDL stimulates FLG significantly along with supporting genes involved in SC homeostasis.
A recent study demonstrates that particulate matters significantly reduces FLG levels in a human keratinocyte model. Barrier building by HydraSynol IDL is further confirmed by a human skin tape-stripping clinical study that compared the effects of two lotions.
Taken together, these results demonstrate that use of Synastol TC and HydraSynol IDL can provide a holistic protection of skin damage originating from pollution and/or blue light. Syanstol TC possesses robust dual inhibitory activity against oxidative and inflammatory stress, whereas HydraSynol IDL reduces and repairs skin barrier dysfunction via multiple pathways, which helps reduce skin damage and improve skin appearance, said the company.