US Patent No. 10,300,009 B2
(Michelle Hines, Geetha Kalahasti, Tiffany Florence, David Gan) Mary Kay Inc.,
Addison, TX, has patented method of treating inflamed skin by reducing tumor necrosis factor alpha (TNF-α) or vascular endothelial growth factor (VEGF) production in skin cells. The method comprising topically applying to inflamed skin, a composition comprising an aqueous extract of Opuntia ficus-indica tuna, Opuntia ficus-indica nopales, or a combination thereof to reduce TNF-α or VEGF production in skin cells to treat the inflamed skin, wherein the composition further comprises at least 50 weight percent water.