Exosomes are powerful vectors of intercellular communication with a direct impact on the metabolism and behavior of target cells. These extracellular vesicles are at the heart of major biological processes and are of great interest in the areas of basic biology, health and therapeutic technologies, in particular regenerative medicine. In spite of this, there has been relatively little work on the role of exosomes on hair growth.
The results obtained in joint work with the team of Prof. Aberdam have demonstrated intercellular communication between dermal fibroblasts and the dermal papilla, the “nerve center” of the hair follicle. Exosomes from fibroblasts stimulate the secretion of Norrin, a ligand that activates the ß-catenin pathway that is involved in hair growth.
Using biological models in vitro and ex vivo mimicking androgenetic alopecia, Silab has developed Hairgenyl, an active ingredient capable of acting on this newly discovered exosomal communication system between the dermis and the hair follicle to stimulate the regrowth of hair. This new data on the mechanism of action extends the findings from numerous tests already conducted on this natural ingredient with proven efficacy.