• Login
    • Join
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Formulary
    • Exclusives
    • Top Companies
    • Raw Materials
    • End-User
    • Packaging
    • Directories
    • Events
    • Jobs
    • More
  • Magazine
  • News
  • Formulary
  • Exclusives
  • Top Companies
  • Raw Materials
  • End-User
  • Packaging
  • Directories
  • Events
  • Jobs
  • Current / Back Issues
    Features
    Columns
    Editorial
    Digital Edition
    eNewsletter Archive
    Our Team
    Editorial Guidelines
    Subscribe Now
    Advertise Now
    Top Features
    A Conversation with the Responsible Flushing Alliance

    Nice-Pak Meets Consumer Demands

    Wipes Manufacturers Meet Demand Surge

    Home Care Wipes: Sustainability in Sharper Focus as Cleaning Frenzy Simmers Following Pandemic

    The Cannabis Glow Up
    Online Exclusives
    Association News
    Breaking News
    Financial News
    Industry News
    International
    Marketing News
    New Products
    News Front
    Packaging News
    Patents
    Personnel
    Regulations
    Snapshots
    Top News
    Live From Shows
    Top News
    Qosmedix Brings CSR to the Forefront in New Initiative

    Spectrum Brands Acquires Rejuvenate Household Cleaning Products

    Pravana Joins PETA’s Beauty without Bunnies Program

    A New Chief Digital Officer at L'Oréal

    CEW Seeks Entries for Beauty Creators Awards
    Blog
    Online Exclusives
    Infographics
    Podcasts
    Whitepapers
    Videos
    Expert's Opinion
    HappiTV
    eBook
    Surveys
    International Top 30 Report
    Top 50 Report
    Top Companies
    9. Avon Products

    16. Kosé

    7. Beiersdorf

    9. Mary Kay

    43. Atlantic Coast Brands
    Actives
    Functional Ingredients
    Pigments
    Polymers
    Preservatives
    Surfactants

    CEW Seeks Entries for Beauty Creators Awards

    L’Oréal Successfully Defends Itself In Patent Infringement Lawsuit

    The Estée Lauder Companies Is Beauty Inspired, Values Driven

    HCPA Mid-Year Meeting Adds Keynote

    CP Kelco's Progress Toward 2022 Sustainability Objectives
    Air Care/Environmental Fragrance
    AP/Deo
    Color Cosmetics
    Disinfectants
    Fine Fragrance
    Hair Care
    Household Cleaning
    I&I Marketplace
    Laundry Care
    Oral Care
    OTC/Medicated
    Packaging
    Personal Cleansers
    Skin Care
    Sun Care
    Testing

    Qosmedix Brings CSR to the Forefront in New Initiative

    Spectrum Brands Acquires Rejuvenate Household Cleaning Products

    Pravana Joins PETA’s Beauty without Bunnies Program

    A New Chief Digital Officer at L'Oréal

    CEW Seeks Entries for Beauty Creators Awards
    Lab Equipment
    Mixing
    Packaging
    Testing

    Qosmedix Brings CSR to the Forefront in New Initiative

    Pact Collective Is New Non-Profit Recycling Take-Back Program for Beauty

    New Beauty Brand sk*p Wants to Break Addiction to Plastic

    Arbonne's One Year Anniversary as a B Corp

    Admix Appoints COO to Advance Manufacturing, Supply Chain & Regulatory Compliance
    Contract Manufacturing / Private Label Directory
    Buyer's Guide
    Add New Company
    Corporate Profiles
    International Buyers Guide Companies
    Praan Naturals

    Resolute Oil

    Lubrizol Life Science

    Centerchem Inc

    KLK OLEO
    Live From Shows
    Meetings
    Webinars
    Snapshots
    • Magazine
      • Current / Back Issues
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Formulary
    • Directories
      • Buyer's Guide
      • Contract Manufacturing / Private Label Directory
      • Corporate Profiles
      • Add Your Company
    • Raw Materials
      • Actives
      • Functional Ingredients
      • Pigments
      • Polymers
      • Preservatives
      • Surfactants
    • End-User
      • Air Care/Environmental Fragrance
      • AP/Deo
      • Color Cosmetics
      • Disinfectants
      • Fine Fragrance
      • Hair Care
      • Household Cleaning
      • I&I Marketplace
      • Laundry Care
      • Oral Care
      • OTC/Medicated
      • Packaging
      • Personal Cleansers
      • Skin Care
      • Sun Care
      • Testing
    • Packaging
      • Lab Equipment
      • Mixing
      • Packaging
      • Testing
    • Top Companies
      • International Top 30 Report
      • Top 50 Report
    • Online Exclusives
    • Experts Opinion
    • Slideshows
    • HappiTV
    • Videos
    • Podcasts
    • eBook
    • Infographics
    • Blog
    • Whitepapers
    • Surveys
      • R & D Salary Survey
      • Sales & Marketing Salary Survey
    • Job Banks
    • Events
      • Industry Events
      • Live from show Events
      • Webinars
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    Isosorbide Di-(Linoleate/Oleate) Treats Xerotic Pruritic Skin

    Sytheon publishes study in the Journal of Investigative Dermatology.

    Isosorbide Di-(Linoleate/Oleate) Treats Xerotic Pruritic Skin
    Related CONTENT
    • L’Oréal Successfully Defends Itself In Patent Infringement Lawsuit
    • TFF Names 2021 Honorees for Lifetime Achievement Perfumer and Hall of Fame
    • Ashland Donates $20,000 To Help Plant Trees
    • The Estée Lauder Companies Is Beauty Inspired, Values Driven
    • Multi-Purpose Sustainable 'Just Add Water' Household Cleaner Expands Cleaning Products
    Happi Staff01.14.21
    Sytheon has published a study in the Journal of Investigative Dermatology, profiling mechanistic details of isosorbide di-(linoleate/oleate) and its effectiveness as a treatment for xerotic pruritic skin. The company notes that the breakdown of the epidermal barrier and consequent loss of skin hydration is a feature of skin aging and eczematous dermatitis. Few treatments, however, resolve these underlying processes to provide full symptomatic relief, according to Sytheon. 


    Sytheon has evaluated topical effects of patented isosorbide di-(linoleate/oleate) (IDL) and compared with those of ethyl linoleate/oleate (doi:10.1016/j.jid.2020.09.029 ). Both IDL and ethyl linoleate/oleate downregulated inflammatory gene expression, but IDL more effectively upregulated the expression of genes associated with keratinocyte differentiation (e.g., KRT1, GRHL2, SPRR4). Consistent with this, IDL increased the abundance of epidermal barrier proteins (FLG and involucrin), hydration biomarker protein AQP-9 and prevented cytokine-mediated stratum corneum degradation. IDL also downregulated the expression of unhealthy skin signature genes linked to the loss of epidermal homeostasis and uniquely repressed an IFN-inducible coexpression module activated in multiple skin diseases, including atopic dermatitis & psoriasis. These results demonstrate mechanisms by which IDL improves skin hydration and epidermal barrier function, supporting IDL as an effective intervention for the treatment of xerotic pruritic skin.


    Having secured broad patent coverage, defining the mechanism of IDL, and demonstrating its potential superiority over other linoleates, Sytheon stakes claim through its sister company, Symbionyx Pharmaceu­ticals Inc., to delve into dermatological market.
     
    More info: info@sytheonltd.com
     
    Related Searches
    • Actives
    • OTC/Medicated
    • Skin Care
    Related Knowledge Center
    • Actives
    • Skin Care
    • OTC/Medicated
    Suggested For You
    Beauty By the Numbers: Zooming into Beauty Beauty By the Numbers: Zooming into Beauty
    Henkel Henkel's Joico Brand Celebrates Blonde Hair Color
    Beauty by the Numbers: Ingredient Innovations Beauty by the Numbers: Ingredient Innovations
    How 2020 Changed Aesthetics How 2020 Changed Aesthetics
    What’s Your Hydration IQ? What’s Your Hydration IQ?
    Dove Goes ‘Behind the Filter’ with Lizzo for Body Positivity in Beauty  Dove Goes ‘Behind the Filter’ with Lizzo for Body Positivity in Beauty
    L’Oréal Successfully Defends Itself In Patent Infringement Lawsuit L’Oréal Successfully Defends Itself In Patent Infringement Lawsuit
    TFF Names 2021 Honorees for Lifetime Achievement Perfumer and Hall of Fame TFF Names 2021 Honorees for Lifetime Achievement Perfumer and Hall of Fame
    Ashland Donates $20,000 To Help Plant Trees Ashland Donates $20,000 To Help Plant Trees
    The Estée Lauder Companies Is Beauty Inspired, Values Driven The Estée Lauder Companies Is Beauty Inspired, Values Driven
    Multi-Purpose Sustainable Multi-Purpose Sustainable 'Just Add Water' Household Cleaner Expands Cleaning Products
    FDA Cites Disinfection Issues at Proposed Vaccine Production Site FDA Cites Disinfection Issues at Proposed Vaccine Production Site
    CP Kelco CP Kelco's Progress Toward 2022 Sustainability Objectives
    Robertet Appoints Reichert as Perfumer Robertet Appoints Reichert as Perfumer
    Kiehl’s Launches Sustainable Pouch Refillables for Hair Care, Skin Care Kiehl’s Launches Sustainable Pouch Refillables for Hair Care, Skin Care

    Related Breaking News

    • Color Cosmetics | Fine Fragrance | Hair Care | Skin Care
      A New Chief Digital Officer at L

      A New Chief Digital Officer at L'Oréal

      Asmita Dubey succeeds Lubomira Rochet.
      Tom Branna, Editorial Director 04.23.21

    • Actives | Color Cosmetics | Fine Fragrance | Functional Ingredients | Hair Care | Personal Cleansers | Pigments | Skin Care | Sun Care
      CEW Seeks Entries for Beauty Creators Awards

      CEW Seeks Entries for Beauty Creators Awards

      Deadline for entry is May 6, 2021.
      Tom Branna, Editorial Director 04.23.21

    • Actives | Skin Care
      L’Oréal Successfully Defends Itself In Patent Infringement Lawsuit

      L’Oréal Successfully Defends Itself In Patent Infringement Lawsuit

      Delaware court rules Carmel Labs’ complaint invalid based on indefiniteness.
      Tom Branna, Editorial Director 04.23.21


    • Color Cosmetics | Fine Fragrance | Packaging | Skin Care
      Pact Collective Is New Non-Profit Recycling Take-Back Program for Beauty

      Pact Collective Is New Non-Profit Recycling Take-Back Program for Beauty

      Credo, MOB Beauty and Hudson’s Bay are founding members.
      Christine Esposito, Managing Editor 04.22.21

    • Color Cosmetics | Fine Fragrance | Hair Care | Skin Care
      It

      It's Official! L'Oréal Gets New CEO on May 1

      As reported, Nicolas Hieronimus succeeds Jean-Paul Agon.
      Tom Branna, Editorial Director 04.21.21

    • Hair Care | Packaging | Personal Cleansers | Skin Care
      New Beauty Brand sk*p Wants to Break Addiction to Plastic

      New Beauty Brand sk*p Wants to Break Addiction to Plastic

      Uses proprietary paper-based container that can hold up in the shower and its own bio-fermented honey extract.
      Christine Esposito, Managing Editor 04.21.21


    • Actives | Air Care/Environmental Fragrance | Disinfectants | Functional Ingredients | Household Cleaning | I&I Marketplace | Insect Control | Polymers | Surfactants
      HCPA Mid-Year Meeting Adds Keynote

      HCPA Mid-Year Meeting Adds Keynote

      Online event set for May 24-27, 2021.
      Tom Branna, Editorial Director 04.21.21

    • Skin Care
      Clinique’s #ZitHappens TikTok Challenge Celebrates ‘Skin Positivity’

      Clinique’s #ZitHappens TikTok Challenge Celebrates ‘Skin Positivity’

      Campaign rolls out today.
      Christine Esposito, Managing Editor 04.21.21

    • Actives | Functional Ingredients | Hair Care | Personal Cleansers | Skin Care
      CP Kelco

      CP Kelco's Progress Toward 2022 Sustainability Objectives

      Accomplishments include 12% reduction in water intensity and world class safety performance.
      Tom Branna, Editorial Director 04.21.21


    • Skin Care
      Kiehl’s Launches Sustainable Pouch Refillables for Hair Care, Skin Care

      Kiehl’s Launches Sustainable Pouch Refillables for Hair Care, Skin Care

      Save on average 80% more plastic than a typical Kiehl’s single-use product.
      Melissa Meisel, Associate Editor 04.20.21

    • Color Cosmetics | Skin Care
      Amazon Adds SCS’ Carbon Neutral Certification to Its Climate Pledge Friendly Program

      Amazon Adds SCS’ Carbon Neutral Certification to Its Climate Pledge Friendly Program

      Certifies products to multiple internationally recognized carbon neutral standards.
      Melissa Meisel, Associate Editor 04.20.21

    • Skin Care
      Cosphatec Introduces Cosphaderm Dicapo Natural

      Cosphatec Introduces Cosphaderm Dicapo Natural

      A blend with natural caprylyl glycol.
      Charles Sternberg, Assistant Editor 04.20.21


    • Color Cosmetics | Skin Care
      P&G Reports Solid Cash Results in Q3 of Fiscal 2021

      P&G Reports Solid Cash Results in Q3 of Fiscal 2021

      Net sales were $18.1 billion, a five percent increase versus the prior year.
      Charles Sternberg, Assistant Editor 04.20.21

    • Skin Care
      Jergens Launches Mother’s Day Campaign

      Jergens Launches Mother’s Day Campaign

      Shines a light on nontraditional and under-recognized moms.
      Charles Sternberg, Assistant Editor 04.19.21

    • Actives | Functional Ingredients | Hair Care | Personal Cleansers | Polymers | Preservatives | Skin Care | Sun Care | Surfactants
      Jeen International Celebrates Its 25th Anniversary

      Jeen International Celebrates Its 25th Anniversary

      Its entrepreneurial approach to beauty has attracted more than 3,000 customers around the world.
      Tom Branna, Editorial Director 04.19.21

    Trending
    • It's Official! L'Oréal Gets New CEO On May 1
    • Sunscreen On The Spot
    • A New Chief Digital Officer At L'Oréal
    • Clinique’s #ZitHappens TikTok Challenge Celebrates ‘Skin Positivity’
    • K18 Biomimetic Hairscience Debuts In Salons
    Breaking News
    • Qosmedix Brings CSR to the Forefront in New Initiative
    • Spectrum Brands Acquires Rejuvenate Household Cleaning Products
    • Pravana Joins PETA’s Beauty without Bunnies Program
    • A New Chief Digital Officer at L'Oréal
    • CEW Seeks Entries for Beauty Creators Awards
    View Breaking News >
    CURRENT ISSUE

    CBD Inside & Out

    • The Cannabis Glow Up
    • Mary Jane's Botanicals
    • A Closer Look at cbdMD
    • Is Cannabidiol Coming to Your City or Hamlet?
    • USDA's Final Rule on Hemp
    • A CBD Packaging Evolution
    • CBD Food & Supplement Market Is in Limbo
    • CBD New Product Development
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    Study Finds Omega-3 Index is Strong Risk Predictor of Premature Death
    Ashland Supports the Nature Conservancy Forest Restoration Effort to Help Plant a Billion Trees
    Martin Bauer Announces Installation of Agile Filling System at Bethlehem, PA Facility
    Coatings World

    Latest Breaking News From Coatings World

    Axalta Coating Systems Announces $625 Million Increase to Share Repurchase Program Authorization
    CPMA Expands its Community, Adds 3 New Member Companies in Q1
    Axalta Wins Three 2021 Edison Awards
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    LG Expands Diagnostic Medical Monitor Line
    Getinge Heart Lung Machine Becomes Available for European Hospitals
    Getinge Receives FDA Clearance for Multiple Products
    Contract Pharma

    Latest Breaking News From Contract Pharma

    Lonza to Build Small Molecule Manufacturing Complex in Visp
    RDIF, Minapharm to Make Over 40M Doses of the Sputnik V Vaccine in Egypt
    Bora Pharmaceuticals Completes Health Canada Inspection
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    KKW Launches Fragrance Bundle with Jeff Leatham
    Love Beauty and Planet Announces Sustainability Initiatives
    Coty Shares Long-Term Strategy
    Happi

    Latest Breaking News From Happi

    Qosmedix Brings CSR to the Forefront in New Initiative
    Spectrum Brands Acquires Rejuvenate Household Cleaning Products
    Pravana Joins PETA’s Beauty without Bunnies Program
    Ink World

    Latest Breaking News From Ink World

    Kumon North America Adds Speedmaster XL 106 from Heidelberg
    Acrylic Resins Market Worth $21.9 Billion by 2025: MarketsandMarkets
    SE-DA Invests in Kornit Presto S
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Ravenwood introduces water resistant linerless paper
    Ashland commits to forest restoration
    Epson upgrades SurePress demo facility
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Fibertex Nonwovens Announces European Investments
    Savaré Strengthens Technical Support for the Americas
    FiberVisions, Avgol Partner with Polymateria
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    FDA Clears Orthofix's 3D-Printed FORZA Titanium TLIF Spacer System
    Patients Conclude Clinical Visits in Knee Osteoarthritis Treatment Study
    SeaSpine Begins Limited Rollout of WaveForm TO 3D-Printed Interbodies
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    Identiv, Ameta International Announce US, Canadian Distribution Partnership
    Adesis Achieves ISO 9001:2015 Certification
    Louis Widmer SA Complies with EU Anti-Counterfeiting Directive with Zebra Technologies’ Solution

    Copyright © 2021 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login