Charles Sternberg, Assistant Editor04.01.21
Gattefossé’s EleVastin is a targeted solution to gravity-induced skin sagging. The ingredient strengthens the elasticity of the skin, giving it the support needed to cope with downward pressure.
How it Works
The efficacy of EleVastin has been demonstrated using various models of increasing complexity. The ingredient boosts key proteins involved in the synthesis and maintenance of functional elastic fibers: elastin, fibrillin-1 and fibulin-5.
It also protects elastic fibers against their degradation by elastases. Through this mechanism of action, it ensures an increase of the density of elastic fibers coupled with an augmented skin elasticity. These last outcomes have been obtained using an advanced spheroid model developed in our cell culture laboratory.
Clinical Trial Results
Tested at 1% only, on 37 volunteers, the ingredient proved its capacity to reduce drooping of the lower face. Skin elasticity significantly improved vs. the placebo. Facial contours were better defined, and deep vertical wrinkles were significantly reduced. A novel and original measure of the effects of gravity on facial morphology was adopted, confirming the ability of EleVastin to limit the impact of gravity on aging signs of the face.
100% Natural Origin Content
One of the plants used in EleVastin, Murraya koenigii, has been used for hundreds of years in ayurvedic medicine and in cuisine. In association with our local, long-time partner, leafy stems of the Murraya koenigii tree are manually harvested from fertilizer-free plots in the preserved environment of La Reunion island. Perfect traceability is ensured from the tree to Gattefossé laboratories. A rich pool of synergistic phytomolecules is obtained using an innovative blend of solvents from plant origin and gentle extraction process. This results in a 100% natural origin content according to the norm ISO 16128 and a COSMOS approved ingredient.
“The phytochemical content of Murraya koenigii is both very rich and well described, which has made it possible to adopt a methodical research strategy for plant extraction. By adjusting the polarity of the solvents, we have been able to target more specifically certain molecular families such as flavonoids, phenolic acids or alkaloids. In parallel, in our laboratories, and also in partnership with experts in proteomics and biomechanics, we have developed innovative in vitro evaluation models. They enabled us to achieve a very comprehensive demonstration of the biological efficacy,” said Boris Vogelgesang, R&D director cosmetic actives.
“The clear reproducibility of the results obtained with EleVastin on different types of skin models is a true assurance of the ingredient’s efficacy. Furthermore, its high naturality profile is the outcome of years of research, finetuning solvents compositions and searching the perfect fit with plant material. We are very proud to provide the cosmetic market with this robust and truly natural active ingredient,” explained Laurie Canel, product marketing leader, personal care actives.
How it Works
The efficacy of EleVastin has been demonstrated using various models of increasing complexity. The ingredient boosts key proteins involved in the synthesis and maintenance of functional elastic fibers: elastin, fibrillin-1 and fibulin-5.
It also protects elastic fibers against their degradation by elastases. Through this mechanism of action, it ensures an increase of the density of elastic fibers coupled with an augmented skin elasticity. These last outcomes have been obtained using an advanced spheroid model developed in our cell culture laboratory.
Clinical Trial Results
Tested at 1% only, on 37 volunteers, the ingredient proved its capacity to reduce drooping of the lower face. Skin elasticity significantly improved vs. the placebo. Facial contours were better defined, and deep vertical wrinkles were significantly reduced. A novel and original measure of the effects of gravity on facial morphology was adopted, confirming the ability of EleVastin to limit the impact of gravity on aging signs of the face.
100% Natural Origin Content
One of the plants used in EleVastin, Murraya koenigii, has been used for hundreds of years in ayurvedic medicine and in cuisine. In association with our local, long-time partner, leafy stems of the Murraya koenigii tree are manually harvested from fertilizer-free plots in the preserved environment of La Reunion island. Perfect traceability is ensured from the tree to Gattefossé laboratories. A rich pool of synergistic phytomolecules is obtained using an innovative blend of solvents from plant origin and gentle extraction process. This results in a 100% natural origin content according to the norm ISO 16128 and a COSMOS approved ingredient.
“The phytochemical content of Murraya koenigii is both very rich and well described, which has made it possible to adopt a methodical research strategy for plant extraction. By adjusting the polarity of the solvents, we have been able to target more specifically certain molecular families such as flavonoids, phenolic acids or alkaloids. In parallel, in our laboratories, and also in partnership with experts in proteomics and biomechanics, we have developed innovative in vitro evaluation models. They enabled us to achieve a very comprehensive demonstration of the biological efficacy,” said Boris Vogelgesang, R&D director cosmetic actives.
“The clear reproducibility of the results obtained with EleVastin on different types of skin models is a true assurance of the ingredient’s efficacy. Furthermore, its high naturality profile is the outcome of years of research, finetuning solvents compositions and searching the perfect fit with plant material. We are very proud to provide the cosmetic market with this robust and truly natural active ingredient,” explained Laurie Canel, product marketing leader, personal care actives.
