12.05.22
Sytheon announces a publication on the synergistic anti-inflammatory effects of isosorbide fatty acid diesters in cytokine-induced tissue culture models of atopic dermatitis.
Atopic dermatitis (eczema) is a chronic condition that makes skin red and itchy. Flares occur periodically due to epidermal barrier disruption to the TH-2 mediated inflammation process. It is common in children, but can occur at any age. Topical emollients are a cornerstone of disease management.
This study evaluated the efficacy of two plant-derived oil derivatives, isosorbide di-(linoleate/oleate) (HydraSynol IDL) and isosorbide dicaprylate (HydraSynol DOI), using AD-like tissue culture models. Treatment of reconstituted human epidermis with cytokines led to significant reduction in inflammatory and neurogenic pruritus mediators. These results demonstrated anti-inflammatory mechanisms of isosorbide fatty acid diesters in AD-like skin models. These findings highlight the multifunctional benefits of HydraSynol IDL and DOI as therapeutic candidates to treat atopic dermatitis.
Current study complements an earlier study published by the company (J Investigative Dermatology, 2021, 141:1416-1427) on IDL which has shown to stimulate pro-differentiation gene expression to restore the epidermal barrier and improve skin hydration.
