UC-Davis, CA researchers have published a placebo controlled clinical study on the benefits of Synoxyl AZ (Acetyl Zingerone) in Journal of Cosmetic Dermatology, 2020 May 5. doi: 10.1111/jocd.13464.

 
Sytheon collaborated with UC-Davis researchers on this study which reveals that Synoxyl AZ delivers significant improvement in photoaging related skin benefits as well as skin sensitivity through well explored mechanisms of action. The skin benefits were explored through a double-blind placebo controlled randomized clinical study.
 
According to the study, there was a significant decrease in average wrinkle severity (p=0.019; Mean=-25.7% change), total wrinkle volume (p=0.003; Mean=-30.1 % change), pigment intensity (p=0.021; Mean=-25.6% change), and redness intensity (p=0.035; Mean=-20.7% change) in the AZ group after eight weeks compared to the placebo. Acetyl zingerone is well tolerated with daily use. No itching, burning, or stinging was noted by study participants. Additionally, AZ treatment maintained skin microbiome diversity, with a >20% increase in skin friendly staphylococcus epidermidis.