Navin M. Geria, Chief Scientific Officer AyurDerm Technologies, LLC07.02.18
Many health conscious consumers understand the value of antioxidant supplements and topicals. Allied Market Research has estimated the global antioxidants market generated $2.92 billion in 2015 and predicted it would reach $4.53 billion by 2022, registering a CAGR of 6.42% during the forecast period (Nutraceuticals World, 3/17). Scientists at the University of Otago in New Zealand, were trying to correct levels of oxidative stress in cells and the energy imbalances that occur in these conditions. After a decade of research and $50 million in costs, what they found is briefly discussed in this column. Scientists have discovered a way to support mitochondria, which in turn, has beneficial effects across the entire cell and slows the processes normally associated with aging. This exciting new advance in antioxidant technology, MitoQ (mitoquinol mesylate), is scientifically proven to be hundreds of times more effective than other coenzyme Q10 supplements. It actually gets inside the cell to deliver antioxidant support directly to where it is needed. It helps to reduce the cellular free radical damage that contributes to many of the symptoms of aging and various health disorders.
National Institute of Aging (NIA), funded by the US government, normally selects for testing each year a very small number of promising compounds with exceptional potential to reverse the aging process. MitoQ made the list because it is a powerful antioxidant that re-energizes body, cell by cell, in a unique way that was published in more than 200 articles. As a result,
MitoQ garnered the attention of leading scientists from around the world.
Mitochondria
The mitochondria are primarily the batteries of the cells. If the batteries fail, the cell ultimately dies, or in some situations, the cell might begin to replicate out of control and become cancerous. Every cell in our body, with the exception of red blood cells, contains mitochondria, which create the energy to keep the cell alive. If these mitochondria do not function properly, we can get very sick and, eventually die. Healthy mitochondria are critical for the health of all our cells. They can become damaged or dysfunctional, when the energy they create is less than the free radicals they produce, and they are unable to repair themselves or increase their numbers in their host cell.
Specific medications such as acetaminophen, statins, glyphosate (found in RoundUp weed killer) and heavy metals such as lead, mercury and aluminum can be toxic to mitochondria.1 When everything is working optimally, the mitochondria are healthy and are functioning at the top of their game. Problems develop when the mitochondria are compromised. MitoQ antioxidant, protects mitochondria (our cellular batteries), the organelles inside our cells that power our energy. As we age, both mitochondria and antioxidant supplies start to decline, we cannot fight the damage to our skin and body from free radicals like we used to when we were younger. MitoQ is a new type of antioxidant that protects mitochondria.
MitoQ scientists have found a way to deliver an antioxidant right to the mitochondria inside your cells, where almost 95% of body’s free radicals are generated. These free radicals gradually damage the health of internal organs as well as skin as one ages. Skin begins to look dull, losing its youthful glow. It is clearly obvious that maintaining healthy mitochondria is the key to staying healthier and younger longer. MitoQ uses electrostatic approach, which alters the molecule in such a way that it carries a positive charge, which is the key to its claims of greater uptake. This changing of the electrostatic charge revitalizes the mitochondria, allowing it to repair the cell and allow it to get on with what it did when it was younger. No other product to date has been able to achieve this.
There are many theories of aging being constantly debated worldwide. One prominent theory holds that there is a natural decline in antioxidants and increased oxidation markers that occur with age take toll on our metabolic processes and organs particularly, the brain, heart and liver.
As a by-product, the free radicals are produced, which are kept in check by the body’s own supply of antioxidants such as coenzyme Q10. As we know, the popularity of coenzyme Q10, particularly in supplements, received a boost by the rise in the prescription of statin drugs which deplete the body’s natural stores of coenzyme Q10. The problem with this ingredient has always been surrounding its bio-availability. The base molecule called ubiquinone, is poorly absorbed, leading to a need for higher dosages. In order to get around this, some suppliers offer coenzyme Q10 in the ubiquinol form, the reduced form as it appears in the body, and claim higher bioavailability for the ingredient. As our levels of coenzyme Q10 are depleted with age, the body is less able to produce collagen and elastin, leading to wrinkled, sallow, less supple and firm skin.
A boost of coenzyme Q10 increases the production of both collagen and elastin, as well as stimulates cell activity in general. Healthy skin cells can rid themselves of toxins and make the best use of nutrients, resulting in healthier skin which shows on the outside. If coenzyme Q10 can penetrate the cell’s mitochondria, it can be truly powerful in combating skin aging. Scientists and dermatologists have recommended skin care formulations to contain a minimum of 0.5% coenzyme Q10. MitoQ is a new patented molecule that has been clinically proven to get coenzyme Q10 to cells. Furthermore, by providing a high level of antioxidant protection, cells start to function optimally leading to an overall anti-aging effects. The MitoQ Company offers both oral supplements and topical skin care products using MitoQ technology, according to CEO Greg McPherson.
Exciting Technology
MitoQ is an exciting advance in antioxidant technology because it attaches a positive charge to the antioxidant part of coenzyme Q1O (the mitochondria’s own natural antioxidant). Over 90% of the cell’s energy comes from the mitochondria. Diminishing levels of coenzyme Q10 in the cell is one of the most reliable biomarkers of aging. Clinical studies show that it selectively targets and protects mitochondria, to help reduce oxidative stress and support energy.
MitoQ’s unique delivery system allows it to be both a nutraceutical and also a cosmeceutical, since it supports cell function inside, via consuming a nutraceutical supplement and outside, by being an “active” of a skin care product.
Rerferences
Navin M. Geria
Chief Scientific Officer AyurDerm Technologies, LLC
navin@AyurDerm.com
Navin Geria, former Pfizer Research Fellow is a cosmetic and pharmaceutical product development chemist and the chief scientific officer of AyurDerm Technologies LLC, which provides Ayurvedic, natural and cosmeceutical custom formulation development and consulting services to the spa-wellness-dermatology industries. He has launched dozens of cosmeceutical and ayurvedic anti-aging products. Geria has more than 30 years of experience in the personal care industry and was previously with Clairol, Warner-Lambert, Schick-Energizer, Bristol-Myers and Spa Dermaceuticals. He has nearly 20 US patents and has been published extensively. Geria edited the “Handbook of Skin-Aging Theories for Cosmetic Formulation Development” focus book published in April 2016 by Harry’s Cosmeticology. He is a speaker, moderator and chairman at cosmetic industry events.
National Institute of Aging (NIA), funded by the US government, normally selects for testing each year a very small number of promising compounds with exceptional potential to reverse the aging process. MitoQ made the list because it is a powerful antioxidant that re-energizes body, cell by cell, in a unique way that was published in more than 200 articles. As a result,
MitoQ garnered the attention of leading scientists from around the world.
Mitochondria
The mitochondria are primarily the batteries of the cells. If the batteries fail, the cell ultimately dies, or in some situations, the cell might begin to replicate out of control and become cancerous. Every cell in our body, with the exception of red blood cells, contains mitochondria, which create the energy to keep the cell alive. If these mitochondria do not function properly, we can get very sick and, eventually die. Healthy mitochondria are critical for the health of all our cells. They can become damaged or dysfunctional, when the energy they create is less than the free radicals they produce, and they are unable to repair themselves or increase their numbers in their host cell.
Specific medications such as acetaminophen, statins, glyphosate (found in RoundUp weed killer) and heavy metals such as lead, mercury and aluminum can be toxic to mitochondria.1 When everything is working optimally, the mitochondria are healthy and are functioning at the top of their game. Problems develop when the mitochondria are compromised. MitoQ antioxidant, protects mitochondria (our cellular batteries), the organelles inside our cells that power our energy. As we age, both mitochondria and antioxidant supplies start to decline, we cannot fight the damage to our skin and body from free radicals like we used to when we were younger. MitoQ is a new type of antioxidant that protects mitochondria.
MitoQ scientists have found a way to deliver an antioxidant right to the mitochondria inside your cells, where almost 95% of body’s free radicals are generated. These free radicals gradually damage the health of internal organs as well as skin as one ages. Skin begins to look dull, losing its youthful glow. It is clearly obvious that maintaining healthy mitochondria is the key to staying healthier and younger longer. MitoQ uses electrostatic approach, which alters the molecule in such a way that it carries a positive charge, which is the key to its claims of greater uptake. This changing of the electrostatic charge revitalizes the mitochondria, allowing it to repair the cell and allow it to get on with what it did when it was younger. No other product to date has been able to achieve this.
There are many theories of aging being constantly debated worldwide. One prominent theory holds that there is a natural decline in antioxidants and increased oxidation markers that occur with age take toll on our metabolic processes and organs particularly, the brain, heart and liver.
As a by-product, the free radicals are produced, which are kept in check by the body’s own supply of antioxidants such as coenzyme Q10. As we know, the popularity of coenzyme Q10, particularly in supplements, received a boost by the rise in the prescription of statin drugs which deplete the body’s natural stores of coenzyme Q10. The problem with this ingredient has always been surrounding its bio-availability. The base molecule called ubiquinone, is poorly absorbed, leading to a need for higher dosages. In order to get around this, some suppliers offer coenzyme Q10 in the ubiquinol form, the reduced form as it appears in the body, and claim higher bioavailability for the ingredient. As our levels of coenzyme Q10 are depleted with age, the body is less able to produce collagen and elastin, leading to wrinkled, sallow, less supple and firm skin.
A boost of coenzyme Q10 increases the production of both collagen and elastin, as well as stimulates cell activity in general. Healthy skin cells can rid themselves of toxins and make the best use of nutrients, resulting in healthier skin which shows on the outside. If coenzyme Q10 can penetrate the cell’s mitochondria, it can be truly powerful in combating skin aging. Scientists and dermatologists have recommended skin care formulations to contain a minimum of 0.5% coenzyme Q10. MitoQ is a new patented molecule that has been clinically proven to get coenzyme Q10 to cells. Furthermore, by providing a high level of antioxidant protection, cells start to function optimally leading to an overall anti-aging effects. The MitoQ Company offers both oral supplements and topical skin care products using MitoQ technology, according to CEO Greg McPherson.
Exciting Technology
MitoQ is an exciting advance in antioxidant technology because it attaches a positive charge to the antioxidant part of coenzyme Q1O (the mitochondria’s own natural antioxidant). Over 90% of the cell’s energy comes from the mitochondria. Diminishing levels of coenzyme Q10 in the cell is one of the most reliable biomarkers of aging. Clinical studies show that it selectively targets and protects mitochondria, to help reduce oxidative stress and support energy.
MitoQ’s unique delivery system allows it to be both a nutraceutical and also a cosmeceutical, since it supports cell function inside, via consuming a nutraceutical supplement and outside, by being an “active” of a skin care product.
Rerferences
- Dr. A Danenberg, W. B. Journal vol.27, Nov.4, 2017
Navin M. Geria
Chief Scientific Officer AyurDerm Technologies, LLC
navin@AyurDerm.com
Navin Geria, former Pfizer Research Fellow is a cosmetic and pharmaceutical product development chemist and the chief scientific officer of AyurDerm Technologies LLC, which provides Ayurvedic, natural and cosmeceutical custom formulation development and consulting services to the spa-wellness-dermatology industries. He has launched dozens of cosmeceutical and ayurvedic anti-aging products. Geria has more than 30 years of experience in the personal care industry and was previously with Clairol, Warner-Lambert, Schick-Energizer, Bristol-Myers and Spa Dermaceuticals. He has nearly 20 US patents and has been published extensively. Geria edited the “Handbook of Skin-Aging Theories for Cosmetic Formulation Development” focus book published in April 2016 by Harry’s Cosmeticology. He is a speaker, moderator and chairman at cosmetic industry events.
