US Patent No. 10,300,009 B2 (Michelle Hines, Geetha Kalahasti, Tiffany Florence, David Gan) Mary Kay Inc
. has patented a method of treating inflamed skin by reducing tumor necrosis factor alpha (TNF-α) or vascular endothelial growth factor (VEGF) production in skin cells. The method entails topically applying to inflamed skin, a composition comprising 0.01wt.% to 0.5wt.% of an aqueous extract of Opuntia ficus-indica tuna, Opuntia ficus-indica nopales, or a combination thereof to reduce TNF-α or VEGF production in skin cells to treat the inflamed skin, wherein the composition further comprises at least 50wt.% water.