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New Synthetic Peptide Derivative from DSM


Syn-Up, Syn-Star and more on display at stand J70.

DSM (stand J70) is launching its first synthetic peptide derivative in the Corneocare range. Syn-Up gives skin the power to fight dryness. DSM researchers found that skin resilience, the ability of skin to recover from external stresses such as cold and wind, is essential to ending consumer frustration. The epidermis has a key function in skin resilience and DSM research has shown that urokinase and plasmin, two serine proteases in the epidermis, play a crucial role in skin resilience.

Syn-Up is billed as a unique patented synthetic peptide derivative that restores the skin’s youthful resilience to dry skin conditions. In extensive in-vitro research, Syn-Up was shown to inhibit urokinase activity by up to 97% and plasmin activity by up to 41%. Syn-Up demonstrated a perceivable defense against dry skin conditions and unpleasant sensations when applied in vivo. Skin resilience was evaluated in a 29-day study which revealed that even after repeated stress the skin’s surface is smoother and more hydrated with Syn-Up.

In other peptide news, DSM's Syn-Star peptide showed a global anti-aging and mattifying effect in a study on Caucasian, Asian and African skin. The enzyme PLOD3 (procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3) is known to be important for the stability of intermolecular collagen crosslinks, according to the company. New in-vitro tests confirmed that Syn-Star stimulates PLOD3, increasing collagen stability, specifically in mature skin, by a factor of more than 4. Data from other recent research revealed a positive effect of Syn-Star on sebum flow. In an in-vitro assay Syn-Star was shown to inhibit DPP4 (dipeptidyl peptidase-4), a key enzyme involved in sebum flow.

The clinical study was performed on volunteers of three different ethnicities. A product formulated with 4% Syn-Star was tested for 28 days and its efficacy in wrinkle reduction and a mattifying effect confirmed. In a survey of volunteers, 83% of women agreed that they felt more confident and ready for "a fabulous day" after a treatment with Syn-Star  (satisfaction test, average responses from Caucasian, Asian and African participants).

More info: DSM,