RIFM Research Presented at SETAC Europe

Research Institute for Fragrance Materials (RIFM) Principal Scientist Aurelia Lapczynski will make poster and platform presentations at the 35th Annual Meeting of the Society of Environmental Toxicology and Chemistry Europe. SETAC will take place in Vienna, Austria, May 11-15, 2025.

Lapczynski leads RIFM’s Environmental Safety Assessment and Research Programs. She will present a poster titled “Finding the Right Way to Address Potential Mobility – A Case of a Fragrance Material” on May 13. The poster explores practical strategies and standardized testing methods to assess the environmental mobility of fragrance ingredients. It focuses on OECD 106 and OECD 121 protocols and predictive modeling.

Assessing Fragrance Materials’ Mobility

“This research will allow us to assess the applicability and challenges associated with current approaches in assessing mobility when it comes to fragrance materials,” Lapczynski explains. “In addition, the newly generated data will be compared to Koc values generated by available models to evaluate their applicability to fragrance materials.”

“Koc” stands for “organic carbon–water partition coefficient,” and a Koc value reveals how likely a chemical will stick to soil or wash away into water, helping predict its environmental impact.

On May 15, Lapczynski will deliver a platform presentation during the “Advances in Bioaccumulation Science and Assessment” session. The presentation is titled “Comparing the Predictive Capacity of the OECD 319B In vitro Fish Biotransformation Assay to the In vivo OECD 305 Study for a Hydrophobic Organic Chemical.” It is the result of a collaborative effort between RIFM, Givaudan International SA and Eurofins EAG Agroscience, LLC. It demonstrates alternative approaches in the assessment of bioaccumulation.

Eliminating and Minimizing Animal Testing

“Eliminating and minimizing animal testing by using New Approach Methodologies (NAMs), when applicable, and scientifically justifying these new approaches is a priority for RIFM when conducting risk or hazard assessments,” said Lapczynski. “This study shows that currently available and well-validated approaches – in this case, an in vitro OECD 319 assay – should be solidly anchored in a tiered assessment approach as an efficient and sustainable means of evaluating bioaccumulation.”

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