Innosya Cosmetic Ingredients Launches Range of Patented Biotech Ingredients for Skin Care

Lesaffre, a 170-year-old French company specializing in fermentation and microorganisms, launched its new cosmetics activity: Innosya Cosmetic Ingredients. Leveraging Lesaffre’s extensive library of microorganisms, Innosya’s team of cosmetic professionals selected three fermented actives clinically proven to prevent skin aging.

FERMENTED ACTIVES FOR LONGEVITY AT ALL LIFE STAGES

While skin aging remains at the very heart of consumers’ interests, their needs are not being fully met across all age groups. On one end of the spectrum, young consumers are increasingly seeking personalized “pre-juvenation” solutions, driven by a fear of looking older than their peers. Meanwhile, the 35-44 age range faces rapidly evolving skin care needs due to the many external stressors their complexions endure from their busy urban lifestyles. As collagen levels deplete, their established skin care routines often fall short, and this demographic lacks the information needed to adapt their regimen.¹ At the other end of the age spectrum, consumers entering menopause are largely ignored by the industry, even as their skin undergoes a profound life stage transition. Personalized solutions to address the unique challenges of menopausal skin aging remain in high demand. 

To address these different needs, Innosya Cosmetic Ingredients offers a complete range of patented actives made by fermentation to overcome these challenges in an ethical, sustainable way.

Skinosya™ Chondro: The first vegan chondroitin sulfate, an ally of GLP-1 skins.

Chondroitin sulfate is a glycosaminoglycan naturally occurring in the body. While this ingredient has been leveraged in cosmetics, the commercially available versions typically come from animal sources such as bovine, porcine, or marine cartilage. Innosya has developed an alternative: Skinosya™ Chondro, the world’s first chondroitin sulfate produced through precision fermentation. 

This innovative approach not only addresses ethical and environmental concerns but also offers significant technical advantages. Skinosya™ Chondro has a lower molecular weight compared to animal-derived chondroitin sulfate, resulting in enhanced bioavailability and functionality. It also boasts higher purity levels and increased sulfation, which amplifies its efficacy as a skin care active. 

Both being glycosaminoglycans, Skinosya™ Chondro is a true skin architect binding proteins in the ECM and distributing water evenly in stratum corneum whereas hyaluronic acid builds volume essentially by binding water. Skinosya™
Chondro reinforces the skin’s barrier integrity and supports the dermal structure by stimulating collagen and elastin production while inhibiting degradation enzymes, making it a valuable ally to prevent collagen and elastin loss and MMPs production induced by GLP-1. Clinical studies have demonstrated
Skinosya™ Chondro’s ability to improve firmness, elasticity, density, and facial contours, while reducing the appearance of sagging and fine lines. This active represents an innovative solution for formulators seeking to deliver high-performance, cruelty-free skin care products, aligned with consumers’ needs. 

Skinosya™ Salidroside: a fermented alternative to rhodiola root extract, targeting stressed skin.

Salidroside, the primary adaptogenic bioactive derived from rhodiola roots, has long been used to increase the body’s resistance to various stressors. Indeed, prolonged exposure to internal and external stressors can disrupt skin’s natural metabolism, weaken the barrier, accelerate collagen breakdown, increase oil production, and trigger inflammatory conditions. Its potent anti-stress, antioxidant, and anti-inflammatory properties make it a valuable ingredient for skin care. However, the growing popularity of salidroside has led to challenges in its supply and production. The rhodiola plant has notoriously long growing cycles and low yields, leading to fluctuating costs and supply. Increased demand has resulted in the overexploitation of rhodiola, threatening the survival of the plant species. 

Skinosya™ Salidroside avoids the supply chain and environmental issues associated with rhodiola root extraction. Using precision fermentation allows for the production of high-purity salidroside with consistent quality and traceability, while eliminating the impact on the rhodiola plant population. Skinosya™ Salidroside strongly reduces cortisol levels and mitigates the effects of stress on the skin. It reinforces the skin’s natural barrier function. defends against oxidative stress while supporting mitochondrial longevity. The ingredient is clinically proven to alleviate skin fatigue and leaves a more dewy and comfortable skin. Skinosya™ Salidroside helps address the impact of stress on skin, while meeting the evolving needs of today’s high-paced urban lifestyles.

Skinosya™ SAG: a bioavailable glutathione, for menopausal aging prevention. 

Skinosya™ SAG is a new patented form of S-Acetyl Glutathione designed to prevent and address the effects of menopause-related skin changes.

As women transition through menopause, their skin faces a unique set of challenges that can accelerate the visible signs of aging. One key factor is the imbalance of iron levels that often occurs during this hormonal shift. Recent studies have shown that the estrogen deficiency of menopause can cause elevated iron loads in the body. Compounding this issue is the simultaneous depletion of intracellular glutathione (GSH) levels. Glutathione is a powerful antioxidant that plays a crucial role in defending skin cells against oxidative damage. With diminished GSH, the skin’s ability to protect itself is severely compromised. This breakdown of antioxidant defenses can trigger dramatic lipid peroxidation in skin cell membranes, initiating a process called ferroptosis – a form of programmed cell death that accelerates the visible hallmarks of menopausal skin aging, such as dryness, thinning, poor healing, reduced radiance, and a weakened skin barrier.

Made through precision fermentation process, Skinosya™ SAG offers enhanced bioavailability compared to conventional glutathione. It outperforms standard glutathione in replenishing GSH levels in skin cells, effectively protecting them from iron-dependent oxidative damage. Clinically tested, Skinosya™ SAG has been shown to reduce the appearance of wrinkles, enhance complexion radiance, and improve skin tone evenness. By incorporating Skinosya™ SAG into your formulations, you can deliver a powerful, biotech-derived glutathione that strengthens the skin’s natural defenses against ferroptosis and hormonal aging, helping customers maintain a youthful glow.

INNOSYA IS BENEFITING FROM LESAFFRE’S GLOBAL PRESENCE

With Lesaffre’s 81 factories worldwide, Innosya is benefiting from a global presence, ensuring scalability, supply reliability and competitive leadtimes.

Meanwhile, Innosya opened a formulation laboratory called “La Villa Cosmétique” near Paris. At this facility, the Innosya team ensures the formulability of their ingredients and prepares prototypes to showcase the full potential of their actives in market-similar products.

To discover more about Innosya Cosmetic Ingredients range, visit their website:
www.lesaffre.com/activities/innosya-cosmetic-ingredients

Reference
1. Beauty Cultures Podcast, 2026 Skin Care Trends, featuring Mintel