P&G Mouth Rinse Has Cetylpyridinium Chloride

US Patent No. 9,241,885 B2; Procter & Gamble has an oral care mouthrinse composition that is formulated with cetylpyridinium chloride as essential antimicrobial active; a pharmaceutically-acceptable liquid carrier comprising a major proportion of water, glycerin as humectant, a sweetening agent selected from sucrose, glucose, saccharin, dextrose, levulose, lactose, mannitol, sorbitol, fructose, maltose, thaumatin, aspartame, D-tryptophan, dihydrochalcones, acesulfame, cyclamate and salts thereof; and a flavoring agent selected from oil of wintergreen, oil of spearmint, clove bud oil, menthol, anethole, methyl salicylate, eucalyptol, cassia, 1-menthyl acetate, sage, eugenol, parsley oil, oxanone, alpha-irisone, marjoram, lemon, orange, propenyl guaethol, cinnamon, vanillin, thymol, linalool, cinnamaldehyde glycerol acetal. The composition is essentially free of anionic, nonionic or amphoteric surfactants, glycol solvents and anti-staining additives and free of excipients having a negative effect on bioavailability of the quaternary ammonium agents. The composition has at least 65% bioavailability as determined by a Disk Retention Assay to deliver a bioavailable level of quaternary ammonium antimicrobial agent required for efficacy. It also has no more than 5% ethyl alcohol for improved taste and suitability for safe use by consumers, and has an aesthetically acceptable clear appearance and is antibiotic free.