A Breakthrough in Aging?

Before you start flirting with that blonde-haired guy at the bar, think about your spawn, according to scientists who say that they've identified the first gene that is responsible, in part, for gray hair. That gene, dubbed IRF4, is also associated with blonde or lighter-colored hair. That makes sense, because melanin is the pigment that paints hair with the chestnut, golden or raven hues of youth. With age, the melanocytes that produce the color in hair follicles can slow down. And you start going gray.

“You think about hair graying as the absence of melanin,” said Kaustubh Adhikari, a statistical genetics postdoc at University College London and lead author of the study, which was published in Nature Communications. Adhikari was quoted in an NPR interview.
 

Gray hair is more common in people of European origin, as is lighter hair. That makes sense, Adhikari says. “You would sort of think of hair graying as an unintended consequence of selecting for this hair color.”


In other words, if you decide to marry a blonde, don't be surprised if your kids someday turn gray. People of Asian and African ancestry also go gray, but less often than do Europeans.


“You would expect that they would have genes that influence graying,” Adhikari says. “We just haven't found them yet.”
 

The scientists discovered the gray gene by studying the scalps and facial hair of 6,630 volunteers in Brazil, Colombia, Chile, Mexico and Peru. The researchers took photographs and asked about natural hair color. The participants had a mix of European, Native American and African ancestry.
 

Then the scientists performed genetic analyses called genome-wide association scans that look for common variants, and matched them with appearance. Ten new variants popped out; gray hair was matched with one. Others influence unibrow, balding, eyebrow thickness and hair structure.

Still, genetics isn't necessarily destiny. Adhikari figures that the IRF4 variant accounts for about 30% of gray hair, with environmental factors—including, perhaps, stress—accounting for the rest.