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Forms thin film and induces remineralization by binding with phosphate-calcium ions present in saliva.
April 3, 2023
By: Christine Esposito
Editor-in-Chief
US Patent No. 11,612,555 B2 (Joo Hwang Park, Ji Hyun Lee); Hysensbio, Gwacheon-si, South Korea, has been awarded US patent for an oral care composition that alleviates dentin hyperesthesia. It is comprised a peptide consisting of an amino acid sequence of the following Formula 1: K—Y-R1-R2-R3-R4-R5-R6-R7-R8 wherein R1 is arginine (R), lysine (K) or glutamine (Q); R2 is arginine (R) or glutamine (Q); R3, R4, and R5 are arginine (R) or lysine (K), respectively; R6 is asparagine (N) or serine(S); and R7 and R8 are lysine (K) or tyrosine (Y), respectively. The composition includes 0.00005-0.00015 parts by weight of the peptide, 85-87 parts by weight of purified water, 1.7-2.9 parts by weight of a surfactant, and 0.0045-0.0055 parts by weight of a citric acid hydrate. The composition forms thin film on the surface of the dentin and induces remineralization of the dentin and dentinal tubule by binding with phosphate-calcium ions present dentinal tubules and in saliva.
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