RIFM Imposes March 8 Deadline To Complete Concentration Survey

The Research Institute for Fragrance Materials (RIFM) will complete its Concentration Survey on March 8. 

 

The RIFM Safety Assessment evaluation process focuses on individual fragrance materials, and the process more rapidly incorporates advances in in-vitro and in-silico methodologies. This focus allows RIFM to take advantage of advances in the science of safety evaluations and meet the increasingly stringent requirements from regulatory bodies and the increased expectations of fragrance users.

 

Exposure data are essential for completing a safety assessment for all endpoints. The Creme RIFM Aggregate Exposure Model is a probabilistic aggregate exposure model to calculate total systemic exposure, with distributions used to model various parameters. This model enables the measurement of real-life consumer exposure to a fragrance material. 

 

RIFM has published four publications on the model in the peer-reviewed journal Regulatory Toxicology and Pharmacology. 

 

This spreadsheet lists the materials in this 43nd concentration survey. The file contains two worksheets. The first worksheet contains the 156 fragrance materials included in this survey. 

 

If no exposure data exists, RIFM will not conduct a safety assessment. For natural complex substances (NCSs), the RIFM identifier is more critical than the CAS Number because it incorporates the ISO Standard (ISO 9235) terminology. The concentration data will remain confidential. They are entered into the model, but the data sources will not be available.

 

The information must only be provided by fragrance compounders (companies that blend fragrance ingredients) for marketed fragrance mixtures. Concentrations that are not currently in use should not be entered.

 

The contribution from NCSs in reporting for chemically defined materials must be included. In addition, a column has been added to indicate if the chemically defined material is found in NCSs.

 

Since materials are being re-surveyed (previously surveyed five years ago), data on all of the materials – even if there has been no change since the last survey – must be submitted.

 

If a material is used in a product with dual uses, the concentration should be reported in both product types.

 

Only fragrance ingredients used in “technologies,” which aim to release a fragrance ingredient under certain conditions, should be reported as the fragrance ingredient, not the parent material(s).

Additional product types are included.

 

The total number of formulas sold for each product type must be added. By providing this information, Creme Global will calculate the number of formulas that contain that fragrance ingredient.

 

See the RIFM Portal User Guide here for more information.

 

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