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October 2, 2014
By: TOM BRANNA
Editor
US Patent No. 8,821,920 B2; LTS Lohmann Therapie Systeme AG has patented a patch with a therapeutic compound-impermeable backing layer, a self-adhesive amine-resistant polysiloxane matrix consisting of: a therapeutic compound for treating neuropathic pain which contains about 5-10% by weight of capsaicin or a capsaicin analog or mixture thereof as the therapeutic compound, based on the total weight of the matrix; and diethylene glycol monoethyl ether (DGME) based on the total weight of the matrix. The polysiloxane matrix is a mixture of a polysiloxane of medium tack and a polysiloxane of high tack. The matrix, which contains a silicone oil, comprises 58-85% by weight of self-adhesive polysiloxane and the coating weight of the matrix is between 30-200 g/m2, and a protective film to be removed before use. The matrix contains liquid microreservoir droplets comprising an amphiphilic solvent in which the therapeutic compound is dissolved. The microreservoir droplets comprise a viscosity-increasing additive dissolved in the solvent. The concentration of the therapeutic compound in the microreservoir droplets is between 40-70% by weight of the saturation concentration, wherein the amphiphilic solvent is diethylene glycol monoethyl ether.
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