Clariant’s New Beauty Component Ideal for Anti-Aging Skin Care

Clariant Active Ingredients’ new milk thistle flower extract Celyscence targets aging to recover healthy skin and improve hydration, brightness. Demonstrating its scientifically-proven effectiveness on areas including the aging-sensitive yet often neglected décolleté, Celyscence delivers a new approach for formulators to innovate and differentiate in the healthy aging skin care space. 

 
Senescent cells (fibroblasts) can trigger an unhealthy state of the skin at any age. Chronological aging is associated with the accumulation of senescent fibroblasts and is exacerbated by the impact of regular exterior stressors like pollution and UV light. These fibroblasts alter and generate damage more quickly than their healthy counterparts. They are highly resistant to apoptosis (cell death), they impair biological regenerative and repair functions, and even secrete molecules that damage surrounding cells, turning them senescent. This undermines the ability to maintain a healthy skin structure, causing a long list of age-related disorders, including dull, dehydrated skin, and loss of skin firmness from decreased collagen production. 

 
Celyscence, an active ingredient born from Clariant Active Ingredients x Biospectrum research, is a breakthrough innovation for preventing a decline in skin function and promoting healthy aging skin. The extract draws on the therapeutic properties of milk thistle, using the flowers to achieve particularly wide activity in targeting and counteracting cellular senescence. 

 
Celyscence is proven in vitro to demonstrate a unique combination of selective senolytic and senomorphic effects: pushing senescent cells to apoptosis (senolytic effect) to maximize their elimination and prevent them from irreversibly inducing damage; and alleviating their side effects (senomorphic effect) by downregulating their secretion of molecules that cause additional harm.Further experimental evaluations also show the ability of Celyscence to even reprogram senescent cells and reverse their loss of functionality. For example, contributing to the return of a healthy metabolism by restoring functions like collagen production. Celyscence reinstates the crucial ability of dermal fibroblasts to produce collagen, which shows its ability to reprogram senescent cells. This ultimately ensures aged tissue repair and remodeling efficacy.

The potential of Celyscence in delivering healthy aging properties has been assessed under extreme and real-life conditions.
 
Studies Show Success
In-vivo testing focused on the lower face, throat and décolleté area, one of the less explored areas for skin care and generally the most neglected by consumers, to determine its suitability for mature skin care, healthy aging products and neck firming creams. Its ability to successfully hydrate skin, increase brightness and radiance, re-firm the chest and neck, address issues with sagging skin and redefine features, were confirmed.
 
A volunteer group of 30 women aged between 50 and 60, all presenting visible wrinkles on the neck and the décolleté, were enrolled. For 56 days, one half of the panel applied a product containing 3% Celyscence on the throat and chest, and the other half a placebo product. Clinical measurements were done after 14, 28 and 56 days. Twice daily for 14 days, all participants also applied either a cream containing 3% Celyscence or a placebo cream on one half of the face to enable specific and quick face observation. The evaluation took place in fall.