12.08.22
The Research Institute for Fragrance Materials and expert panel for fragrance safety have published the paper, “An Endpoint-Specific Framework for Read-Across Analog Selection for Human Health Effects,” in the peer-reviewed journal Chemical Research in Toxicology.
Read-across is a safety assessment approach in which study data on one chemical can be used as a proxy to support the safe use of a structurally similar chemical lacking study data. Dr. Moustakas discussed the importance and impact of the newly-published paper in a recent Ask a RIFM Scientist posting.
“Endpoint specificity in read-across analog selection makes read-across a more scientific process,” he explained. “In addition, it expands the potential read-across options RIFM scientists have, which allows them to ensure the safety of more fragrance ingredients while avoiding extra testing and saving animal lives.”
The read-across paper is available open-access for free download here. RIFM recently hosted its first science symposium, as reported in Happi.