• Login
    • Join
  • Subscribe Free
    • Magazine
    • eNewsletter
    Checkout
    • Magazine
    • News
    • Formulary
    • Exclusives
    • Top Companies
    • Raw Materials
    • End-User
    • Packaging
    • Directories
    • Events
    • Jobs
    • More
  • Magazine
  • News
  • Formulary
  • Exclusives
  • Top Companies
  • Raw Materials
  • End-User
  • Packaging
  • Directories
  • Events
  • Jobs
  • Current / Back Issues
    Features
    Columns
    Editorial
    Digital Edition
    eNewsletter Archive
    Our Team
    Editorial Guidelines
    Subscribe Now
    Advertise Now
    Top Features
    Stepping into the Spotlight for 2021

    The Independent Beauty Association Supports Sensible Reform

    Essential Workers

    A Clean Commitment

    Deliver & Delight
    Online Exclusives
    Association News
    Breaking News
    Financial News
    Industry News
    International
    Marketing News
    New Products
    News Front
    Packaging News
    Patents
    Personnel
    Regulations
    Snapshots
    Top News
    Live From Shows
    Top News
    Amyris To Enter Cannabinoid Beauty

    RB Buys Queen V

    NY's 1,4-Dioxane Law May Impact Concentrated Cleaners

    Sabinsa's Top Scientist Addresses US FDA

    Ipsy Adds New Personal Care Brand
    Blog
    Online Exclusives
    Infographics
    Podcasts
    Whitepapers
    Videos
    Expert's Opinion
    HappiTV
    eBook
    Surveys
    International Top 30 Report
    Top 50 Report
    Top Companies
    18. New Avon

    37. Helen of Troy

    15. Revlon

    2. Colgate

    27. Sisley
    Actives
    Functional Ingredients
    Pigments
    Polymers
    Preservatives
    Surfactants

    Amyris To Enter Cannabinoid Beauty

    RB Buys Queen V

    NY's 1,4-Dioxane Law May Impact Concentrated Cleaners

    Sabinsa's Top Scientist Addresses US FDA

    Nouryon Expands Board of Directors
    Air Care/Environmental Fragrance
    AP/Deo
    Color Cosmetics
    Disinfectants
    Fine Fragrance
    Hair Care
    Household Cleaning
    I&I Marketplace
    Laundry Care
    Oral Care
    OTC/Medicated
    Packaging
    Personal Cleansers
    Skin Care
    Sun Care
    Testing

    Amyris To Enter Cannabinoid Beauty

    RB Buys Queen V

    NY's 1,4-Dioxane Law May Impact Concentrated Cleaners

    Sabinsa's Top Scientist Addresses US FDA

    Ipsy Adds New Personal Care Brand
    Lab Equipment
    Mixing
    Packaging
    Testing

    Ross Introduces Double Cone Tumble Blender

    Happi Talks: Overnight Labels

    Three Form Vertical Beauty Alliance

    Logo Design Trends for 2021 & Beyond

    Coming Clean About Stink
    Contract Manufacturing / Private Label Directory
    Buyer's Guide
    Add New Company
    Corporate Profiles
    International Buyers Guide Companies
    LipoTrue Inc.

    Jeen International

    QRS (Quality Resourcing Services)

    Praan Naturals

    Centerchem Inc
    Live From Shows
    Meetings
    Webinars
    Snapshots
    • Magazine
      • Current / Back Issues
      • Features
      • Editorial
      • Columns
      • Digital Edition
      • eNewsletter Archive
      • Subscribe Now
      • Advertise Now
    • Breaking News
    • Formulary
    • Directories
      • Buyer's Guide
      • Contract Manufacturing / Private Label Directory
      • Corporate Profiles
      • Add Your Company
    • Raw Materials
      • Actives
      • Functional Ingredients
      • Pigments
      • Polymers
      • Preservatives
      • Surfactants
    • End-User
      • Air Care/Environmental Fragrance
      • AP/Deo
      • Color Cosmetics
      • Disinfectants
      • Fine Fragrance
      • Hair Care
      • Household Cleaning
      • I&I Marketplace
      • Laundry Care
      • Oral Care
      • OTC/Medicated
      • Packaging
      • Personal Cleansers
      • Skin Care
      • Sun Care
      • Testing
    • Packaging
      • Lab Equipment
      • Mixing
      • Packaging
      • Testing
    • Top Companies
      • International Top 30 Report
      • Top 50 Report
    • Online Exclusives
    • Experts Opinion
    • Slideshows
    • HappiTV
    • Videos
    • Podcasts
    • eBook
    • Infographics
    • Blog
    • Whitepapers
    • Surveys
      • R & D Salary Survey
      • Sales & Marketing Salary Survey
    • Job Banks
    • Events
      • Industry Events
      • Live from show Events
      • Webinars
    • About Us
      • About Us
      • Contact Us
      • Advertise With Us
      • Privacy Policy
      • Terms of Use
    Breaking News

    Vaccine for Skin Cancer Shows Promise

    New information from phase 2 clinical trial.

    Related CONTENT
    • NY's 1,4-Dioxane Law May Impact Concentrated Cleaners
    • Sabinsa's Top Scientist Addresses US FDA
    • Weleda Celebrates 100 Years of Beauty
    • Nouryon Expands Board of Directors
    • Flow Launches Collagen Waters
    Happi Staff11.16.20

    A vaccine created to prevent the recurrence of the deadly skin cancer melanoma is about twice as effective when patients also receive two components that boost the number and effectiveness of immune system cells called dendritic cells, according to phase 2 clinical trial results published in Nature Cancer in November.

    These results are important, according to researchers, because most cancer vaccine trials have failed to show clinical efficacy. These results show that adding two immune-boosting components can boost the immune response for not only melanoma patients but possibly also others whose cancers express a protein called the vaccine antigen, which is common in some cancers. 

    Researchers at The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai, working with colleagues at the National Cancer Institute-funded Cancer Immunotherapy Trials Network (CITN) based at the Fred Hutchinson Cancer Research Center, found that adding the small molecule Flt3L, which increases the number of dendritic cells, boosted the vaccine’s effectiveness at producing antibodies and T cells that can later fight melanoma. Adding a second component, called poly-ICLC, also strengthened the dendritic cells’ ability to promote antibodies as well as helper and killer T cells. 

    In the study, 60 patients who had stage 2 or 3 melanoma, and whose cancer was successfully removed via surgery, received the vaccine. Half of the patients received the vaccine alone while the other half received the vaccine with Flt3L and poly-ICLC. 

    The vaccine is designed to target dendritic cells and is composed of an antigen found in melanoma bound to an antibody to increase the chances of binding with dentrici cells. 

    The cocktail of the vaccine, Flt3L, and poly-ICLC nearly doubled the vaccine’s efficacy, according to analysis of the T cells detected in patients’ blood samples after they received four doses over four months. That immune response was seen significantly earlier in the patients who received the cocktail and at much higher levels in many more patients compared to those who received only the vaccine. Researchers found antibodies were still present in blood samples tested 12 weeks after the last dose.

    “This is the first randomized clinical trial to show that an immune response to a cancer vaccine can be potentiated by the addition of Flt3L,” says Nina Bhardwaj, MD, PhD, Director of the Immunotherapy Program at The Tisch Cancer Institute, and first author and a corresponding author on the study. “The response was achieved because Flt3L mobilized dendritic cells, which are the gold standard in promoting cancer immunity, and improved the overall immunogenicity of the vaccine. This may change the approach of increasing efficacy in other cancer vaccines in the future.”

    “These positive results are significant not only for improving cancer vaccines, but also potentially for application to other vaccine platforms,” reported the study’s co-corresponding and senior author Steven Fling, PhD, Director of the CITN Laboratory and Senior Staff Scientist in the Vaccine and Infectious Disease Division at the Fred Hutchinson Cancer Research Center, “and we are extremely grateful and indebted to the patients whose unwavering participation made this demanding clinical protocol a success.”

    These findings also provide a basis for adding immunotherapies called checkpoint inhibitors, which have been successful in treating metastatic melanoma, to vaccines in order to further increase the success in fending off melanoma recurrence. Researchers also plan to follow trial participants over time and measure how many have cancer recurrence to further study the vaccine’s efficacy in each group.

    “Immunotherapy has already shown great promise for patients with metastatic melanoma who would normally have a difficult, sometimes grave, prognosis,” said Philip Friedlander, MD, PhD, Director of the Melanoma Medical Oncology Program at The Tisch Cancer Institute at Mount Sinai and site investigator of the trial. “It’s important to work toward developing effective cancer vaccines that can prevent cancer on their own or in addition to the drugs already available.”

    Related Searches
    • Sun Care
    Related Knowledge Center
    • Sun Care
    Suggested For You
    Mutha Cracks The Code On Vitamin C Mutha Cracks The Code On Vitamin C
    Beauty by the Numbers: Supplement Sensation Beauty by the Numbers: Supplement Sensation
    Drink It In! Drink It In!
    Neutrogena Expands Hydro Boost for Hair Care  Neutrogena Expands Hydro Boost for Hair Care
    NY NY's 1,4-Dioxane Law May Impact Concentrated Cleaners
    Sabinsa Sabinsa's Top Scientist Addresses US FDA
    Weleda Celebrates 100 Years of Beauty Weleda Celebrates 100 Years of Beauty
    Nouryon Expands Board of Directors Nouryon Expands Board of Directors
    Flow Launches Collagen Waters Flow Launches Collagen Waters
    Associations Congratulate Biden & Harris Associations Congratulate Biden & Harris
    David Stanko Joins JPMS David Stanko Joins JPMS
    Ross Introduces Double Cone Tumble Blender Ross Introduces Double Cone Tumble Blender
    Colonial Chemical Announces New Facility Colonial Chemical Announces New Facility
    Ashland Acquires Schülke & Mayr Ashland Acquires Schülke & Mayr's Personal Care Business
    Alastin Named a Fast-Growing Brand Alastin Named a Fast-Growing Brand

    Related Breaking News

    • Skin Care | Sun Care
      Ashland Launches Antaron ECo Gel

      Ashland Launches Antaron ECo Gel

      New ingredient offers a lighter feel ideal for gel, lotion, milk, or spray formulas.
      Happi Staff 01.14.21

    • Sun Care
      Alba Botanica Taps Surfer as Brand Ambassador

      Alba Botanica Taps Surfer as Brand Ambassador

      Women's champion and Olympic medal hopeful will work with brand through 2021.
      Happi Staff 01.13.21

    • Color Cosmetics | Skin Care | Sun Care
      Third Generation To Lead CSR at Clarins

      Third Generation To Lead CSR at Clarins

      Virginie Courtin-Clarins will expand and accelerate ethical, sustainable practices and B Corp certification.
      Happi Staff 01.08.21


    • Skin Care | Sun Care
      Warning Letter Sent To Florida Company

      Warning Letter Sent To Florida Company

      Violations related to Age Blocker and Estro-Lift Day Therapy topical skin care products.
      Happi Staff 12.31.20

    • Sun Care

      Sunscreen Composition

      Contains nanoporous calcium phosphate particles.
      Happi Staff 12.31.20

    • Color Cosmetics | Functional Ingredients | Hair Care | Household Cleaning | Laundry Care | Oral Care | Polymers | Skin Care | Sun Care | Surfactants
      The Best Household & Personal Products of 2020

      The Best Household & Personal Products of 2020

      Did your formula make the Good Housekeeping Institute's list?
      Happi Staff 12.30.20


    • Sun Care
      Raw Elements Hosts World Reef Day 2020

      Raw Elements Hosts World Reef Day 2020

      The virtual event raised awareness & funding for critical organizations’ efforts.
      Happi Staff 12.18.20

    • Actives | Color Cosmetics | Functional Ingredients | Hair Care | Personal Cleansers | Pigments | Polymers | Preservatives | Skin Care | Sun Care | Surfactants

      In-Cosmetics Wins AEO Award

      Recognized for Best Marketing Campaign for In-Cosmetics Global 2019.
      Happi Staff 12.14.20

    • Actives | Color Cosmetics | Functional Ingredients | Hair Care | Personal Cleansers | Skin Care | Sun Care | Surfactants | Testing
      NYSCC Year in Review Webinar

      NYSCC Year in Review Webinar

      Register today for tomorrow's session, which begins at 11am.
      Happi Staff 12.14.20


    • Actives | Color Cosmetics | Functional Ingredients | Hair Care | Packaging | Personal Cleansers | Pigments | Polymers | Preservatives | Skin Care | Sun Care | Surfactants | Testing
      SCC Virtual Annual Meeting

      SCC Virtual Annual Meeting

      Online event starts Monday and it's not too late to register!
      Happi Staff 12.06.20

    • Actives | Functional Ingredients | OTC/Medicated | Skin Care | Sun Care
      J&J Seeks Black Innovators in Skin Care

      J&J Seeks Black Innovators in Skin Care

      Johnson & Johnson issues QuickFire Challenge
      Happi Staff 12.01.20

    • Color Cosmetics | Hair Care | Personal Cleansers | Skin Care | Sun Care
      Who Wants To Be a Millionaire?

      Who Wants To Be a Millionaire?

      If you have beauty AND brains, take it to the bank. Here's a list of investors with cash for your cosmetics.
      Happi Staff 11.28.20


    • Color Cosmetics | Hair Care | Personal Cleansers | Skin Care | Sun Care
      Baby Your Beauty Brand

      Baby Your Beauty Brand

      TBM Brand Lab is determined to co-create a new wave of innovation-led beauty brands.
      Happi Staff 11.26.20

    • Actives | Color Cosmetics | Functional Ingredients | Hair Care | Personal Cleansers | Pigments | Polymers | Preservatives | Skin Care | Sun Care | Surfactants | Testing
      NYSCC Executive Board 2021

      NYSCC Executive Board 2021

      Susanna Fernandes of Tri-K Industries elected chair.
      Happi Staff 11.23.20

    • Actives | Color Cosmetics | Fine Fragrance | Functional Ingredients | Hair Care | Personal Cleansers | Pigments | Skin Care | Sun Care
      CEW Beauty Award Winners

      CEW Beauty Award Winners

      The 26th annual event attracts more than 1,200 entries and 500 brands in 45 categories. Here's the best of the best.
      Happi Staff 11.13.20

    Trending
    • Nu Skin Launches ‘Clean’ Formula Line
    • L'Oréal Bans Animal Hair In Brushes
    • Honest, Refillable Cleaners
    • Formulating Liquid Laundry Detergents
    • Ashland Acquires Schülke & Mayr's Personal Care Business
    Breaking News
    • Amyris To Enter Cannabinoid Beauty
    • RB Buys Queen V
    • NY's 1,4-Dioxane Law May Impact Concentrated Cleaners
    • Sabinsa's Top Scientist Addresses US FDA
    • Ipsy Adds New Personal Care Brand
    View Breaking News >
    CURRENT ISSUE

    January 2021

    • Stepping into the Spotlight for 2021
    • The Independent Beauty Association Supports Sensible Reform
    • Essential Workers
    • A Clean Commitment
    • Deliver & Delight
    • Reusables for Consumables In the Pandemic and Beyond
    • A Rebound for Beauty
    • Beauty Brands Must Prepare for a 'Decade of the Home'
    • A Societal Shift
    • View More >

    Cookies help us to provide you with an excellent service. By using our website, you declare yourself in agreement with our use of cookies.
    You can obtain detailed information about the use of cookies on our website by clicking on "More information”.

    • About Us
    • Privacy Policy
    • Terms And Conditions
    • Contact Us

    follow us

    Subscribe
    Nutraceuticals World

    Latest Breaking News From Nutraceuticals World

    NIH Study Compares Low-Fat, Plant-based to Low-Carb, Animal-Based Diet
    Gadot Positions Mineral Line for Vegan Market
    Nutritfy India to Launch Global Broadcast Channel Covering Nutrition
    Coatings World

    Latest Breaking News From Coatings World

    BASF Begins Implementing Ralignment of Global Business Services Unit
    Nouryon Appoints Curtis Espeland to Board of Directors
    AMETEK Brookfield Opens Media Room at US HQ
    Medical Product Outsourcing

    Latest Breaking News From Medical Product Outsourcing

    Endoscopic Hemostasis Devices Market Valued at $730 Million
    Henry Schein Buys Majority Interest in Prism Medical Products
    Boston Scientific's Vercise Genus DBS Earns FDA Approval
    Contract Pharma

    Latest Breaking News From Contract Pharma

    CONTINUUS Awarded $69.3M DoD Grant
    AbbVie Licenses ProBioGen’s GlymaxX Technology
    WDSrx Expands Warehouse Network
    Beauty Packaging

    Latest Breaking News From Beauty Packaging

    Coty Appoints Chief Procurement Officer
    Lageen Tubes Launches Mono-Material PE Tube Solutions
    Jason Jones Loses Battle with Covid-19
    Happi

    Latest Breaking News From Happi

    Amyris To Enter Cannabinoid Beauty
    RB Buys Queen V
    NY's 1,4-Dioxane Law May Impact Concentrated Cleaners
    Ink World

    Latest Breaking News From Ink World

    Morancé Soudure France Adds Comexi F2 MC 10-color Flexo Press
    THIMM Group Installs 1st Koenig & Bauer CorruFLEX
    Cowan Graphics Adds Fujifilm Inca OnsetX3 HS
    Label & Narrow Web

    Latest Breaking News From Label & Narrow Web

    Gallus planning virtual event for March
    Lemu Group engineers mask-making machine
    Niagara Label upgrades with Nilpeter flexo press
    Nonwovens Industry

    Latest Breaking News From Nonwovens Industry

    Freudenberg to Establish Apparel Interlining Competence Centers
    Minet Adds Spunlace Line in Romania
    Lemu Group Engineers Mask-Making Machine
    Orthopedic Design & Technology

    Latest Breaking News From Orthopedic Design & Technology

    Conformis Enters Development & Supply Agreement with SITES Medical
    Sectra, RSA Biomedical Sign Distribution Agreement for Implant Stability Tool
    Siemens Healthineers’ DR Systems Cleared by FDA
    Printed Electronics Now

    Latest Breaking News From Printed Electronics Now

    UDC Subsidiary Adesis' Website Wins 2020 MarCom Platinum Award
    Roadsimple Modernizes Warehouse Ops with Zebra Technologies
    Graphene Flagship Launches Redesigned Website

    Copyright © 2021 Rodman Media. All rights reserved. Use of this constitutes acceptance of our privacy policy The material on this site may not be reproduced, distributed, transmitted, or otherwise used, except with the prior written permission of Rodman Media.

    AD BLOCKER DETECTED

    Our website is made possible by displaying online advertisements to our visitors.
    Please consider supporting us by disabling your ad blocker.


    FREE SUBSCRIPTION Already a subscriber? Login