03.30.23
As skin ages, hyaluronic acid (HA), the skin component responsible for serving as a natural moisturizing factor, decreases with age. Past studies show that a small amount of skin HA is correlated with the skin sagging index and wrinkle depth, as dermal HA helps skin maintain the extracellular matrix structure effectively. HA loss is caused by hyaluronidase HYAL1/2.
Recent studies revealed that in the dermis, HA is mainly degraded by HYBID, the novel HA cleavage enzyme. The expression level of HYBID is correlated with skin sagging and wrinkle.
Ichimaru Pharcos searched for a material that inhibits the expression of HYBID in fibroblasts and found that an extract of Artemisia capillaris flowers had this effect.
Ichimaru Pharcos searched for a material that inhibits the expression of HYBID in fibroblasts and found that an extract of Artemisia capillaris flowers had this effect.
To inhibit the degradation of HA in fibroblasts to reduce skin sagging and wrinkles, the brand launched the natural cosmetic ingredient HyaluGuard. With continued use, its effects include a reduction of skin wrinkle and skin sagging, an increase of moisture content and protection of HA from degradation.
By way of regulations, HyaluGuard is pending Cosmos-approved certification.
By way of regulations, HyaluGuard is pending Cosmos-approved certification.