US Patent No. 10,471,283 B2 (Rajnish Kohli, Richard Scott Robinson, Richard J. Sullivan, Diane Cummins, Nagaraja Jayaraman, MaryAnn Filadelfi-Keszi); Colgate-Palmolive Company
, New York, has patented a method to treat ameliorate, inhibit, or prevent dry mouth in a person who either has xerostomia, is diagnosed with a disease or injury that predisposes the person to xerostomia or is being treated with a medication that predisposes the person to xerostomia. The method entails administering to the oral cavity of the person a composition comprising a basic amino acid, in free or salt form, and zinc citrate; wherein the basic amino acid is arginine or arginine bicarbonate, and the arginine is L-arginine. The composition further comprises one or more compounds selected from the group consisting of a calcium ion source; a phosphate ion source; a potassium ion source; a magnesium ion source; a fluoride ion source; a flavorant which promotes saliva flow; and a polyol humectant. The fluoride ion source is selected from stannous fluoride, sodium fluoride, potassium fluoride, sodium monofluorophosphate, sodium fluorosilicate, ammonium fluorosilicate, amine fluoride, ammonium fluoride, and combinations thereof.
The composition has a pH between about 6.8 and 7.2.